The reconstituted product has a limited lifetime in solution. Long-term storage in solution should be avoided.
E7764
Endothelin 1
≥97% (HPLC), powder
Synonym(s):
ET-1
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 μg | Available to ship TODAYfromMILWAUKEE | $71.20 | |
| 50 μg | Available to ship TODAYfromMILWAUKEE | $233.00 | |
| 0.1 mg | Available to ship TODAYfromMILWAUKEE | $397.00 |
About This Item
Empirical Formula (Hill Notation):
C109H159N25O32S5
CAS Number:
Molecular Weight:
2491.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
human
biological source
human
Quality Level
assay
≥97% (HPLC)
form
powder
technique(s)
ELISA: suitable
color
white
solubility
1% acetic acid: >1 mg/mL, H2O: >1 mg/mL
UniProt accession no.
storage temp.
−20°C
SMILES string
[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N4)C(C)C)C(=O)N[C@@H](Cc5cnc[nH]5)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(O)=O
InChI
1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)/t56-,57-,64-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,86-,87-,88-/m0/s1
InChI key
ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N
Gene Information
human ... EDN1(1906)
General description
Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells.[1] This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes.[2]
Application
Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1,[3] for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).[4]
Biochem/physiol Actions
Endothelin is a potent agonist for ETA and ETB endothelin receptors.
Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions.[1] ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells.[5] The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects.[2] The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests.[6]
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Other Notes
A synthetic peptide with the sequence of human and porcine Endothelin 1.
Lyophilized from 0.1% TFA in H2O
The biological source is human endothelin, which shares the same sequence
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay - | assay - | assay ≥95% (HPLC), ≥95% (SDS-PAGE) |
| technique(s) ELISA: suitable | technique(s) immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250, radioimmunoassay: 1:25,000, western blot: suitable | technique(s) immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source mouse | biological source mouse | biological source human |
| form powder | form - | form buffered aqueous solution | form lyophilized |
| Gene Information human ... EDN1(1906) | Gene Information human ... EDN1(1906) | Gene Information human ... EDN1(1906) | Gene Information human ... DLL1(28514) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Product Information Sheet
Monika Komar et al.
Cardiovascular ultrasound, 12, 31-31 (2014-08-08)
The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for
Stephen Wedgwood et al.
American journal of physiology. Lung cellular and molecular physiology, 288(3), L480-L487 (2004-11-09)
Similar to infants born with persistent pulmonary hypertension of the newborn (PPHN), there is an increase in circulating endothelin-1 (ET-1) and decreased endothelial nitric oxide synthase (eNOS) gene expression in an ovine model of PPHN. These abnormalities lead to vasoconstriction
Javid Safa et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(4), 781-787 (2014-06-28)
End-stage renal disease (ESRD) is a complex illness that involves different organs including the lungs. We studied the pulmonary function tests, arterial blood gases (ABG) and plasma endothelin-1 (ET-1) levels to check whether there is any change in their levels
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E7764-10UG | 04061833608456 |
| E7764-.1MG | 04061833608449 |
| E7764-50UG | 04061833608463 |
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What is the storage information for the reconstituted product? How long are aliquots stable at -20C?
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