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E8750

α-Estradiol

synthetic (organic), ≥98% (TLC), Endogenous estrogen receptor agonist, powder

Synonym(s):

1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol

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Pack SizeSKUAvailabilityPrice
100 mg
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$131.00
500 mg
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$527.00
1 g

Estimated to ship onMay 27, 2026fromMILWAUKEE

$826.00

About This Item

Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
57-91-0
Molecular Weight:
272.38
NACRES:
NA.77
PubChem Substance ID:
24894682
UNSPSC Code:
12352200
EC Number:
200-354-8
MDL number:
MFCD00064144
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

$131.00

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Product Name

α-Estradiol, powder, ≥98% (TLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to slight yellow

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

InChI key

VOXZDWNPVJITMN-SFFUCWETSA-N

Gene Information

human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208)

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

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α-Estradiol powder, ≥98% (TLC)

Sigma-Aldrich

E8750

α-Estradiol

β-Estradiol-6-one

Sigma-Aldrich

K1001

β-Estradiol-6-one

Estriol ≥97%

Sigma-Aldrich

E1253

Estriol

β-Estradiol 17-acetate ≥99%

Sigma-Aldrich

E7879

β-Estradiol 17-acetate

form

powder

form

powder

form

powder

form

powder

assay

≥98% (TLC)

assay

≥98.00% (TLC)

assay

≥97%

assay

≥99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

ethanol: 50 mg/mL, clear, colorless

solubility

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless to faintly yellow

solubility

pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow

solubility

chloroform: 50 mg/mL, clear, colorless to faintly brownish-yellow

color

white to slight yellow

color

-

color

-

color

-

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pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000518182
0000518182
0000518180
0000518181
0000518181

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Raphaël Bonnet et al.
Frontiers in oncology, 10, 557643-557643 (2020-11-27)
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive subtype of leukemia for which important progress in treatment efficiency have been made in the past decades to reach a cure rate of 75%-80% nowadays. It is nevertheless mandatory to find new
Wolf Dietrich et al.
Fertility and sterility, 95(4), 1247-1255 (2010-12-07)
To clarify, whether uterine endothelial proliferation could be regulated via an autocrine estrogen producing mechanism or direct actions of testosterone. In vitro study. Tertiary care facility. Human myometrial tissue obtained from 40 women undergoing hysterectomy without further intrauterine pathology. Cell
C Y Cheng et al.
Fertility and sterility, 32(5), 566-570 (1979-11-01)
In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effect on human spermatozoal motility. DL-Norgestrel at concentrations
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Global Trade Item Number

SKUGTIN
E8750-1G04061833608845
E8750-100MG04061833608838
E8750-500MG04061832850078

Questions

1–5 of 5 Questions  

  1. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. How can I dissolve α-Estradiol, Product No. E8750?

    1 answer

    1. This chemical is soluble in ethanol at 50 mg/mL with heating, and in DMSO at 27 mg/mL. Use of freshly prepared solutions is recommended.

      Helpful?

  4. Is Product E8750, α-Estradiol, tested in cell culture?

    1 answer

    1. No specific suitability tests for cell culture applications have been performed by Sigma. The product is not sterile and has not been tested for endotoxins.

      Helpful?

  5. What is the difference between α-Estradiol (Product No. E8750) and β-Estradiol?

    1 answer

    1. α-Estradiol has been reported as being less feminizing than β-Estradiol while still having significant biological properties.  See Moos, W.H., et al, "17α-Estradiol:a less-feminizing estrogen", Drug Development Research, 69(4), 177-184 (2008).

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