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E9012

Endothelin 2 human

≥97% (HPLC), powder

Synonym(s):

ET-2

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50 μg

Available to ship TODAYfromMILWAUKEE

$438.00
$372.30
0.1 mg

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$774.00
$657.90

About This Item

Empirical Formula (Hill Notation):
C115H160N26O32S4
CAS Number:
123562-20-9
Molecular Weight:
2546.92
NACRES:
NA.77
PubChem Substance ID:
24894687
UNSPSC Code:
51111800
MDL number:
MFCD00133306
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
200

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Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P20800

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]2CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC3=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc6ccc(O)cc6)C(=O)N[C@@H](Cc7ccccc7)C(=O)N2)[C@@H](C)CC)C(=O)N[C@@H](Cc8c[nH]c9ccccc89)C(O)=O

InChI

1S/C115H160N26O32S4/c1-11-59(9)93(113(170)132-82(115(172)173)41-64-46-120-71-27-19-17-25-68(64)71)141-114(171)94(60(10)12-2)140-105(162)81(44-91(150)151)130-99(156)75(37-57(5)6)125-103(160)79(42-65-47-118-55-121-65)128-109(166)86-52-175-174-51-69(117)95(152)133-83(48-142)108(165)138-87-53-176-177-54-88(111(168)139-92(58(7)8)112(169)131-77(39-62-29-31-66(145)32-30-62)100(157)126-76(101(158)137-86)38-61-22-14-13-15-23-61)136-97(154)73(33-34-89(146)147)123-96(153)72(28-20-21-35-116)122-104(161)80(43-90(148)149)129-98(155)74(36-56(3)4)124-102(159)78(40-63-45-119-70-26-18-16-24-67(63)70)127-106(163)84(49-143)134-107(164)85(50-144)135-110(87)167/h13-19,22-27,29-32,45-47,55-60,69,72-88,92-94,119-120,142-145H,11-12,20-21,28,33-44,48-54,116-117H2,1-10H3,(H,118,121)(H,122,161)(H,123,153)(H,124,159)(H,125,160)(H,126,157)(H,127,163)(H,128,166)(H,129,155)(H,130,156)(H,131,169)(H,132,170)(H,133,152)(H,134,164)(H,135,167)(H,136,154)(H,137,158)(H,138,165)(H,139,168)(H,140,162)(H,141,171)(H,146,147)(H,148,149)(H,150,151)(H,172,173)/t59-,60-,69-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,92-,93-,94-/m0/s1

InChI key

MLFJHYIHIKEBTQ-IYRKOGFYSA-N

Gene Information

human ... EDN2(1907)

General description

Endothelin-2 (ET-2) is a member of the endothelin family, which also includes ET-1 and ET-3. ET-2 is the human ortholog of mouse and rat vasoactive intestinal contractor (VIC). These peptides are characterized by two disulfide linkages. ET-2 is predominantly expressed in cerebrum, stomach, intestine, ovary, uterus and testis.[1]

Biochem/physiol Actions

Endothelin-2 (ET-2) has a regulatory role in multiple cancer types, such as breast and clear cell renal cell carcinoma (ccRCC). It is overexpressed during early stages of non-metastasized ccRCC, and is thought have a role in the progression of the same.[1] It is a hypoxia-related factor, and might have protective action against cell death in neuronal diseases. It acts as a ligand for ET-A and ET-B receptors, which results in vasoconstriction.[2] A985 polymorphism in this gene is thought play a protective role in cardiovascular diseases, but it acts as a susceptibility factor in atrial fibrillation in hypertrophic cardiomyopathy patients.[3] In neural retina, it suppresses angiogenesis, and facilitates the tip cell state in endothelial cells.[4]

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Endothelin 2 human ≥97% (HPLC), powder

Sigma-Aldrich

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Endothelin 2 human

Endothelin 3 human, rat ≥97% (HPLC), powder

Sigma-Aldrich

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Endothelin 3 human, rat

Endothelin 1 ≥97% (HPLC), powder

Sigma-Aldrich

E7764

Endothelin 1

Relaxin-2 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3147

Relaxin-2 human

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

powder

form

powder

form

powder

form

lyophilized

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

white

color

white

color

white

UniProt accession no.

P20800

UniProt accession no.

P13207, P14138

UniProt accession no.

P05305

UniProt accession no.

P04090

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SLBB4533V
021M8727
090M8713
050M1439
129K8715

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Premkumari Kumarathasan et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 21(3), 257-266 (2016-02-24)
There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was
Amir Rattner et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(40), E3830-E3839 (2013-09-18)
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here, we report that constitutive overexpression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell migration across the retinal surface and
Brian M Bot et al.
Human pathology, 43(6), 843-849 (2011-11-04)
Despite the rising incidence of clear cell renal cell carcinoma, the molecular events that support its development and progression remain unclear. Herein, we evaluate the association of endothelin 2 expression with both clear cell renal cell carcinoma development and progression-free
View All Related Papers

Global Trade Item Number

SKUGTIN
E9012-50UG04061832676807
E9012-.1MG04061832676791

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