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E9750

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

Synonym(s):

1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin

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500 mg

Estimated to ship onApril 27, 2026from市川市大町368

¥7,380
1 g

Estimated to ship onApril 27, 2026from市川市大町368

¥9,310
5 g
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¥25,300
25 g
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¥76,300

About This Item

Empirical Formula (Hill Notation):
C18H22O2
CAS Number:
53-16-7
Molecular Weight:
270.37
NACRES:
NA.77
PubChem Substance ID:
24278427
UNSPSC Code:
51111800
EC Number:
200-164-5
MDL number:
MFCD00003620
Beilstein/REAXYS Number:
1915077
Assay:
≥99%
Form:
powder
Quality level:
200

¥7,380

Estimated to ship onApril 27, 2026Details

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Product Name

Estrone, ≥99%

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥99%

form

powder

mp

258-260 °C (lit.)

solubility

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

General description

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:
  • as medium supplement for hormone based degranulation studies of natural killer cells
  • as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
  • as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Show Differences

1 of 1

This Item
PHR1535BP860E1700000
Estrone ≥99%

Sigma-Aldrich

E9750

Estrone

Estrone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1535

Estrone

Estrone British Pharmacopoeia (BP) Reference Standard

BP860

Estrone

Estrone European Pharmacopoeia (EP) Reference Standard

E1700000

Estrone

assay

≥99%

assay

-

assay

-

assay

-

form

powder

form

-

form

crystalline

form

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

room temp

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

-

solubility

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

solubility

-

solubility

-

solubility

-

shipped in

ambient

shipped in

-

shipped in

-

shipped in

-

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

E9750-1G:4.548173379715E12 + E9750-25G:4.548173379722E12 + E9750-5G:4.548173379746E12 + E9750-500MG:4.548173379739E12

jan

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3106V
WXBF4601V
WXBF1727V
BCCJ9107
BCCG0660

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Articles

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids
Lopes-Coelho F, et al.
Molecular and cellular endocrinology, 462(9), 93-106 (2018)
Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
Macek J, et al.
Mediators of Inflammation, 2017(9), 747-749 (2017)
Alina Karabchevsky et al.
Biosensors, 3(1), 157-170 (2013-03-01)
An immobilization protocol was developed to attach receptors on smooth silver thin films. Dense and packed 11-mercaptoundecanoic acid (11-MUA) was used to avoid uncontrolled sulfidization and harmful oxidation of silver nanolayers. N,N'-dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS) were added to make
View All Related Papers

Global Trade Item Number

SKUGTIN
E9750-25G04061833609170
E9750-5G04061833609194
E9750-500MG04061833609187
E9750-1G04061835556779

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