F0427
Fas Ligand human
>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder
Synonym(s):
FasL
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About This Item
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recombinant
expressed in CHO cells
Quality Segment
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer calculated mol wt ~18 kDa, 26-28 kDa by SDS-PAGE
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FASLG(356)
General description
Application
Biochem/physiol Actions
FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-κB (NFκB). NFκB/FASLG pathway facilitates the suppression of p,p′-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E. In CD4+ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
Protein belonging to the tumor necrosis factor (TNF) family of cytokines; induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Analysis Note
Measured by its ability to induce apoptosis in Jurkat cells.
Other Notes
Human Fas Ligand, N-terminal 6X histidine-tagged, encodes amino acids 134-281.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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