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Fas Ligand human

Name: Fas Ligand human
Brand: SIGMA
Price: 952 USD
Availability: InStock

>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder

Synonym(s):

FasL

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Size/SKU	Availability	Price
10 μg	Available to ship TODAYfromMILWAUKEE	$1,120.00 $952.00

About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD01092558

$952.00

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Properties

recombinant

expressed in CHO cells

Quality Segment

100

assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

monomer calculated mol wt ~18 kDa, 26-28 kDa by SDS-PAGE

impurities

endotoxin, tested

UniProt accession no.

P48023

storage temp.

−20°C

Gene Information

human ... FASLG(356)

Description

General description

FASLG (Fas ligand) acts as a ligand for Fas receptor, and is a major protein involved in programmed cell death, apoptosis. Soluble Fas (sFAS) is usually detected in plasma prior to apoptosis.

Application

Fas Ligand (FASLG) human has been used for-

the study of FASLG stimulation in luteal cells obtained from mid-corpus luteum (CL) and
the study of apoptosis induction and intracellular caspase-3 assay in human cells.

Biochem/physiol Actions

FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-κB (NFκB). NFκB/FASLG pathway facilitates the suppression of p,p′-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E. In CD4⁺ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Protein belonging to the tumor necrosis factor (TNF) family of cytokines; induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Analysis Note

Measured by its ability to induce apoptosis in Jurkat cells.

Other Notes

Human Fas Ligand, N-terminal 6X histidine-tagged, encodes amino acids 134-281.

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This Item	SRP3036	F0552	PF033
Sigma-Aldrich F0427 Fas Ligand human	Sigma-Aldrich SRP3036 Fas Ligand human	Sigma-Aldrich F0552 Fas Ligand from mouse	Sigma-Aldrich PF033 Fas Ligand, Human, Recombinant
description >95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder	description recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture	description >95% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder	description Fas Ligand, Human, Recombinant, consists of amino acids 103-281 fused at the N-terminus to a tag-linker peptide. Binds to human, rat, and mouse Fas.
assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE), ≥95% (HPLC)	assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
recombinant expressed in CHO cells	recombinant expressed in CHO cells	recombinant expressed in mouse NSO cells	recombinant expressed in HEK 293 cells
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized	form lyophilized powder	form lyophilized
impurities endotoxin, tested	impurities <0.1 EU/μg endotoxin, tested	impurities endotoxin, tested	impurities <0.1 EU/μg Endotoxin (EU/μg purified protein)
UniProt accession no. P48023	UniProt accession no. P48023	UniProt accession no. P41047	UniProt accession no. -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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