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Anti-Factor IX antibody produced in rabbit

Name: Anti-Factor IX antibody produced in rabbit
Brand: SIGMA
Price: 855 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Factor IX Antibody

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Size/SKU	Availability	Price
1 mL	Check Cart for Availability	$855.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00162406

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), WB

Citations:

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:5,000, western blot: 1:3,000 using using reduced and non-reduced human plasma blots

UniProt accession no.

P00740

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... F9(2158)

Description

General description

Factor IX is a 55 kDa, single chain, vitamin K-dependent plasma zymogen. Factor IX is synthesized in liver parenchymal cells and requires a post-translational, vitamin K-dependent, modification in order to become a mature plasma zymogen. Factor IX concentration in human plasma ranges between 2.5-5 mg/ml and its half-life is ~24 hr. Human factor IX gene is about 40 kb in size and is localized at the distal end of the X-chromosome.

Four and a half LIM domains protein 1 is a protein encoded by the FHL1 gene in humans and is located on human chromosome Xq27.2. Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system. It belongs to peptidase family S1 and its deficiency causes hemophilia B. The proteins belong to a novel family of LIM proteins that are expressed in human skeletal muscle. FHL1 gene is related to carcinogenesis and its inactivation is a frequent event during oral carcinogenesis. FHL1 downregulation in oral squamous cell carcinoma (OSCC) occurs through DNA methylation of the promoter region rather than histone deacetylation or mutation.

Immunogen

human factor IX

Application

Anti-Factor IX antibody produced in rabbit has been used in immunoblotting and Gla enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Hereditary deficiencies or dysfunctions of factor IX cause hemophilia B or "Christmas Disease"(the surname of the first family described).A disulfide bond in factor IX connects the N-terminal sequence (light chain) of factor IX to the C-terminal sequence (heavy chain).Factor IX possesses higher sensitivity, hence even tiny amounts of residual intact can be visualized by F0652.

Specifically reacts with human factor IX. The antibody detects human factor IX in both reduced and non-reduced normal human plasma.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	ZRB1537	F8396	F2145
$Anti-Factor IX antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich F0652 Anti-Factor IX antibody produced in rabbit	Sigma-Aldrich ZRB1537 Anti-Factor IX Antibody, clone 1C9 ZooMAb^® Rabbit Monoclonal	Sigma-Aldrich F8396 Monoclonal Anti-Factor X antibody produced in mouse	Sigma-Aldrich F2145 Monoclonal Anti-Factor V antibody produced in mouse
description IgG fraction of antiserum, buffered aqueous solution	description recombinant, expressed in HEK 293 cells	description clone HX-1, purified immunoglobulin, buffered aqueous solution	description clone HV-1, purified immunoglobulin, buffered aqueous solution
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
biological source rabbit	biological source rabbit	biological source mouse	biological source -
antibody form IgG fraction of antiserum	antibody form purified antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity human	species reactivity mouse, human, rat	species reactivity human	species reactivity human
clone polyclonal	clone 1C9, recombinant monoclonal	clone HX-1, monoclonal	clone HV-1, monoclonal

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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