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F131

FPL 64176

≥98% (HPLC), powder

Synonym(s):

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester

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Pack SizeSKUAvailabilityPrice
25 mg
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$408.00

About This Item

Empirical Formula (Hill Notation):
C22H21NO3
CAS Number:
Molecular Weight:
347.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated, protect from light

$408.00


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Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to beige

solubility

DMSO: >20 mg/mL (Solutions should be freshly prepared.), H2O: insoluble

storage temp.

2-8°C

SMILES string

COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3

InChI

1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3

InChI key

MDMWHKZANMNXTF-UHFFFAOYSA-N

Gene Information

rat ... Cacnb3(25297)

Biochem/physiol Actions

Potent Ca2+ channel (L-type) activator.

Legal Information

Manufactured and sold with permission from Astra Charnwood.

Disclaimer

Photosensitive

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This Item
SML0002SML1937SML2922
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >20 mg/mL (Solutions should be freshly prepared.), H2O: insoluble

solubility

DMSO: >25 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage condition

desiccated, protect from light

storage condition

desiccated

storage condition

desiccated

storage condition

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Zhong Zhang et al.
American journal of physiology. Renal physiology, 299(4), F862-F871 (2010-07-16)
Multiple voltage-gated Ca(2+) channel (Ca(V)) subtypes have been reported to participate in control of the juxtamedullary glomerular arterioles of the kidney. Using the patch-clamp technique, we examined whole cell Ca(V) currents of pericytes that contract descending vasa recta (DVR). The
Stefan I McDonough et al.
Biophysical journal, 88(1), 211-223 (2004-10-27)
FPL 64176 (FPL) is a nondihydropyridine compound that dramatically increases macroscopic inward current through L-type calcium channels and slows activation and deactivation. To understand the mechanism by which channel behavior is altered, we compared the effects of the drug on
Julie A Gaasch et al.
Neurochemical research, 32(10), 1686-1693 (2007-04-04)
Recent studies suggest that iron enters cardiomyocytes via the L-type voltage-gated calcium channel (VGCC). The neuronal VGCC may also provide iron entry. As with calcium, extraneous iron is associated with the pathology and progression of neurodegenerative diseases such as Parkinson's



Global Trade Item Number

SKUGTIN
F131-100MG04061832961606
F131-25MG04061832961613

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