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R-(−)-Fluoxetine hydrochloride

Name: R-(−)-Fluoxetine hydrochloride
Brand: SIGMA
Price: 83.13 EUR

>98% (HPLC), solid

Synonym(s):

(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride

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Pack Size	SKU	Availability	Price
5 mg		Please contact Customer Service for Availability	€97.80 €83.13
25 mg		Please contact Customer Service for Availability	€346.00

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₈NOF₃ · HCl

CAS Number:

114247-09-5

Molecular Weight:

345.79

NACRES:

NA.77

PubChem Substance ID:

24278433

UNSPSC Code:

12352200

MDL number:

MFCD04040065

Assay:

>98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: soluble >10 mg/mL

originator

Eli Lilly

SMILES string

Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1

InChI key

GIYXAJPCNFJEHY-PKLMIRHRSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Description

Application

R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:

to study its effects on the embryoid body (EB) morphogenesis[1]
in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips[2]
to study its effects as an endocrine disruption inducer in Pimephales promelas[3]

Biochem/physiol Actions

Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.[3]

Selective serotonin reuptake inhibitor.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

1 of 1

This Item	F132	343290	M2824
Sigma-Aldrich F1678 R-(−)-Fluoxetine hydrochloride	Sigma-Aldrich F132 Fluoxetine hydrochloride	Sigma-Aldrich 343290 Fluoxetine, Hydrochloride	Sigma-Aldrich M2824 Meptazinol hydrochloride
form solid	form solid	form solid	form powder
assay >98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage condition desiccated	storage condition -	storage condition OK to freeze, desiccated (hygroscopic), protect from light	storage condition -
solubility H₂O: soluble >10 mg/mL	solubility H₂O: 4 mg/mL, DMSO: >5 mg/mL	solubility methanol: 100 mg/mL, water: 5 mg/mL	solubility H₂O: >10 mg/mL
color white	color white	color -	color white to off-white

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pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H315,H318

pcodes

P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant.

Erica L L Warkus et al.

Toxicological sciences : an official journal of the Society of Toxicology, 165(2), 372-388 (2018-06-13)

Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by

Does selective serotonin reuptake inhibitor (SSRI) fluoxetine affects mussel Mytilus galloprovincialis?

Maria Gonzalez-Rey et al.

Environmental pollution (Barking, Essex : 1987), 173, 200-209 (2012-12-04)

Fluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac(®) is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a

Application of multielectrode array (MEA) chips for the evaluation of mixtures neurotoxicity.

Bibiana Scelfo et al.

Toxicology, 299(2-3), 172-183 (2012-06-06)

Cortical neurons grown on multielectrode array (MEA) chips have been shown to be a valuable alternative method to study electrophysiological properties of the central nervous system neurons and to perform functional toxicological screening. Here we studied the effects of binary

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Global Trade Item Number

SKU	GTIN
F1678-5MG	04061832090825
F1678-25MG	04061832090818

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