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F2302

Fractalkine Peptide

Name: Fractalkine Peptide
Brand: SIGMA
Price: 628 EUR

>97% (SDS-PAGE), lyophilized powder, mouse recombinant, expressed in E. coli

Sinonimo/i:

CX3CL-1, Neurotactin

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A voi/SKU	Disponibilità	Prezzo
25 μg	Per informazioni sulla disponibilità, contatta il Servizio Clienti.	628,00 €

Informazioni su questo articolo

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD01635336

628,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

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Proprietà

Nome del prodotto

Fractalkine, Chemokine Domain from mouse, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

biological source

mouse

Quality Segment

100

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.3-3 μg/mL

mol wt

calculated mol wt ~9.5 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

O35188

storage temp.

−20°C

Gene Information

mouse ... Cx3cl1(20312)

Descrizione

General description

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.[1]

Biochem/physiol Actions

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease.[1] In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.[2]

Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX₃C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

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Questo articolo	F135	SRP3214	SRP3218
Sigma-Aldrich F2302 Fractalkine, Chemokine Domain from mouse	Sigma-Aldrich F135 Fractalkine, Extracellular Domain human	Sigma-Aldrich SRP3214 I-TAC (CXCL11) from mouse	Sigma-Aldrich SRP3218 LIX (70 aa) from mouse
description >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder	description ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, suitable for cell culture, lyophilized powder	description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	description recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
assay >97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
recombinant expressed in E. coli	recombinant expressed in NSO cells	recombinant expressed in E. coli	recombinant expressed in E. coli
biological source mouse	biological source human	biological source mouse	biological source mouse
Quality Level 100	Quality Level 200	Quality Level -	Quality Level -
form lyophilized powder	form lyophilized powder	form lyophilized	form lyophilized
mol wt calculated mol wt ~9.5 kDa	mol wt ~90 kDa	mol wt 9.0 kDa	mol wt 7.6 kDa

pictograms

GHS05

signalword

Danger

hcodes

H315,H318

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c