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F2302

Fractalkine Peptide

>97% (SDS-PAGE), lyophilized powder, mouse recombinant, expressed in E. coli

Synonym(s):

CX3CL-1, Neurotactin

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Pack SizeSKUAvailabilityPrice
25 μg

Estimated to ship onApril 27, 2026fromMILWAUKEE

$725.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD01635336

$725.00

Estimated to ship onApril 27, 2026Details

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Product Name

Fractalkine, Chemokine Domain from mouse, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

biological source

mouse

Quality Level

100

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.3-3 μg/mL

mol wt

calculated mol wt ~9.5 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

O35188

storage temp.

−20°C

Gene Information

mouse ... Cx3cl1(20312)

General description

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.[1]

Biochem/physiol Actions

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease.[1] In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.[2]
Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

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Fractalkine, Chemokine Domain from mouse >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

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Follistatin 288 from mouse >95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Sigma-Aldrich

F2177

Follistatin 288 from mouse

assay

>97% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

>95% (SDS-PAGE)

biological source

mouse

biological source

human

biological source

rat

biological source

mouse

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected Sf21 cells

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

lyophilized

form

lyophilized powder

UniProt accession no.

O35188

UniProt accession no.

P78423

UniProt accession no.

P14095

UniProt accession no.

P47931

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H315,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6202
MKCS3980
SLBG1902V
SLBG1902
SLBF4341

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Related Content

Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures.
Long, et al.
Brain sciences, 13 (2023)
Selma Unal et al.
International journal of hematology, 101(2), 114-118 (2014-12-07)
In the present study, we examined the role of fractalkine (Fkn), a member of the chemokine family, in the pathogenesis of sickle cell disease (SCD). Eighty-seven children with sickle cell disease and 55 healthy children were enrolled in the study.
Gemma E White et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(12), 2554-2562 (2014-11-02)
The CX3C chemokine fractalkine (CX3CL1) has a critical role in the development of atherogenesis because apolipoprotein-E-deficient mice lacking CX3CL1 or its receptor CX3CR1 develop smaller plaques and polymorphisms in CX3CR1 are associated with altered risk of cardiovascular disease. CX3CR1 is

Global Trade Item Number

SKUGTIN
F2302-25UG04061833612897

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