This product is native fetuin isolated from fetal bovine serum and should contain both Fetuin A and B. The percentage of each is not determined. It is prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947). The article indicates that the preparation was carried out to obtain both alpha and beta forms of Fetuin. For more information, see https://pubmed.ncbi.nlm.nih.gov/20286396/
F3004
Fetuin from fetal bovine serum
lyophilized powder
Synonym(s):
Fetuin from fetal calf serum
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Available to ship TODAYfromMILWAUKEE | $83.00 |
100 mg | Available to ship TODAYfromMILWAUKEE | $242.00 |
250 mg | Available to ship TODAYfromMILWAUKEE | $406.00 |
1 g | Available to ship TODAYfromMILWAUKEE | $1,320.00 |
About This Item
Form:
lyophilized powder
Biological source:
bovine serum (fetal)
biological source
bovine serum (fetal)
Quality Segment
form
lyophilized powder
technique(s)
HPLC: suitable, MALDI-MS: suitable
impurities
~0.2% free N-acetylneuraminic acid
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... FETUB(504615)
General description
Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.
Application
Fetuin from fetal bovine serum has been used:
- as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
- as a ligand in carbohydrate binding assay of pertussis toxin vaccine
- in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies
Biochem/physiol Actions
In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.
Preparation Note
Further processing of F2379 by gel filtration.
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This Item | |||
|---|---|---|---|
| description lyophilized powder | description - | description lyophilized powder, Essentially fatty acid free | description USA origin, Charcoal Stripped, sterile-filtered, suitable for cell culture |
| technique(s) HPLC: suitable, MALDI-MS: suitable | technique(s) cell culture | mammalian: suitable | technique(s) ELISA: suitable, cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| biological source bovine serum (fetal) | biological source bovine serum | biological source bovine | biological source bovine fetus |
| form lyophilized powder | form lyophilized solid | form lyophilized powder | form - |
| Gene Information bovine ... FETUB(504615) | Gene Information bovine ... AHSG(280988), FETUB(504615) | Gene Information bovine ... ALB(280717) | Gene Information - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
| impurities ~0.2% free N-acetylneuraminic acid | impurities - | impurities ≤0.01% free fatty acid (GC) | impurities ≤10 EU/mL endotoxin (typically ≤1 EU/ml) |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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