Unfortunately, this product is not tested for the presence of plasminogen.
F3879
Fibrinogen from human plasma
50-70% protein (≥80% of protein is clottable)
Fibrinogen from human plasma
1 of 2 reviewers received a sample product or took part in a promotion
Synonym(s):
Factor I
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $110.00 |
250 mg | Estimated to ship onJuly 13, 2026fromCarlos Spegazzini | $249.00 |
1 g | Check Cart for Availability | $676.00 |
5 g | Check Cart for Availability | $2,140.00 |
About This Item
Form:
powder
Biological source:
human plasma
Mol wt:
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa
biological source
human plasma
Quality Segment
form
powder
quality
50-70% protein (≥80% of protein is clottable)
mol wt
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa
concentration
50-70% protein (biuret)
technique(s)
ELISA: suitable
solubility
0.9% NaCl: soluble 10 mg/mL
storage temp.
−20°C
General description
Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin. Fibrinogen has an approximate molecular weight of 340 kDa
Application
Fibrinogen was used in the induction of release of TNF-like cytotoxic factor from murine macrophages.[1] It was used for fabrication of fibrin scaffolds with controlled microscale architecture by a two-photon polymerization-micromolding technique.[2]
Fibrinogen was also used in the development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples.[3]
Fibrinogen from human plasma has been used-
Fibrinogen was also used in the development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples.[3]
Fibrinogen from human plasma has been used-
Biochem/physiol Actions
Acute phase protein that is part of the coagulation cascade of proteins.
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
Features and Benefits
Source material has tested negative for HIV and HBsAg.
Physical form
Lyophilized powder containing ~15% sodium citrate and ~25% sodium chloride.
Preparation Note
The optimal way to solubilize fibrinogen is to layer it on top of warm (37 ºC) saline, as fibrinogen will not dissolve in water. The saline concentration can be in the range of 0.85-0.9%. The fibrinogen-saline solution can be gently agitated, but it must not be vortexed. The fibrinogen will slowly dissolve to give a hazy solution. Fibrinogen may be sterile-filtered, but may not go through a 0.1 μ filter. A 0.2 μ filter is suggested, with positive pressure using a syringe and "button" filter. Vacuum filtration should not be used, since this will lead to breakdown of the molecule during the filtration.
Analysis Note
Protein determined by biuret
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
1 of 1
This Item | |||
|---|---|---|---|
| description 50-70% protein (≥80% of protein is clottable) | description Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains >90% clottable protein. | description Fibrinogen, CAS 9001-32-5, is a soluble plasma glycoprotein that is synthesized in the hepatic parenchymal cells. Contains mpre than 95% clottable protein. | description Plasminogen-Depleted fibrinogen is a native fibrinogen from which plasminogen is depleted using a Lys-agarose column. Contains ≥ 95% clottable proteins. |
| technique(s) ELISA: suitable | technique(s) - | technique(s) - | technique(s) - |
| biological source human plasma | biological source human plasma | biological source - | biological source human plasma |
| concentration 50-70% protein (biuret) | concentration - | concentration - | concentration - |
| mol wt α-chain 63.5 kDa, γ chain 47 kDa (about 4% carbohydrate content), β-chain 56 kDa, soluble dimer 340 kDa | mol wt - | mol wt - | mol wt - |
| form powder | form lyophilized | form lyophilized | form lyophilized |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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I'm evaluating the direct fibrinolytic activity of a bacterial enzyme using your fibrinogen products. Could you confirm if these contain any trace amounts of plasminogen?
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