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F3922

抗線維芽細胞増殖因子受容体3, 細胞外ウサギ宿主抗体

Name: 抗線維芽細胞増殖因子受容体3, 細胞外 ウサギ宿主抗体
Brand: SIGMA
Price: 110000 JPY

affinity isolated antibody, buffered aqueous solution

別名:

抗FGFR-3抗体

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あなたへ/カタログ番号	在庫状況	単価
0.2 mL	カートの在庫状況を確認する	￥110,000

この商品について

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01633348

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB

Citations:

￥110,000

カートの在庫状況を確認する

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特性

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~120 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections, western blot: 1:500 using extract of FGFR-3 transfected cells

UniProt accession no.

P22607

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR3(2261)

詳細

General description

FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.

Immunogen

ヒト繊維芽細胞増殖因子レセプタ-3の細胞外領域のアミノ酸359-372に相当する合成ペプチド。

Application

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:

immunoblotting
immunohistochemistry
immunoprecipitation

Biochem/physiol Actions

Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.

Physical form

0.01M PBS溶液 (pH 7.4, 1%BSA, 15mMアジ化ナトリウム含有)。

Preparation Note

ペプチド-アガロ-スカラムによるアフィニティ-精製で分離しています。

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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当該品目	F0300	SAB1300019	SAB4300637
Sigma-Aldrich F3922 抗線維芽細胞増殖因子受容体3, 細胞外ウサギ宿主抗体	Sigma-Aldrich F0300 抗線維芽細胞増殖因子受容体2, 細胞質ウサギ宿主抗体	$Anti-FGFR4 (N-term) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1300019 Anti-FGFR4 (N-term) antibody produced in rabbit	Sigma-Aldrich SAB4300637 Anti-FGFR4 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description affinity isolated antibody
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level -
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
UniProt accession no. P22607	UniProt accession no. P21802	UniProt accession no. P22455	UniProt accession no. P22455
mol wt antigen ~120 kDa	mol wt antigen 115-125 kDa (doublet)	mol wt -	mol wt ~110 kDa

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flash_point_f

Not applicable

flash_point_c