Key Documents

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit

Name: Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit
Brand: SIGMA
Price: 735 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FGFR-3

Select a Size

Change View

Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$735.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01633348

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB

Citations:

$735.00

Available to ship TODAYDetails

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~120 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections, western blot: 1:500 using extract of FGFR-3 transfected cells

UniProt accession no.

P22607

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR3(2261)

Description

General description

FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.

Immunogen

synthetic peptide corresponding to amino acids 359-372 of the extracellular region of human fibroblast growth factor receptor-3.

Application

Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:

immunoblotting
immunohistochemistry
immunoprecipitation

Biochem/physiol Actions

Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Preparation Note

Affinity isolated on a peptide-agarose column.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	F6796	F5421	F0300
Sigma-Aldrich F3922 Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit	Sigma-Aldrich F6796 Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit	Sigma-Aldrich F5421 Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit	Sigma-Aldrich F0300 Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections, western blot: 1:500 using extract of FGFR-3 transfected cells	technique(s) western blot: 1:2,000 using extract of FGFR-2 transiently transfected cells, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using trypsin-digested, human and animal tissue sections	technique(s) immunoprecipitation (IP): suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections, western blot: 1:400 using an extract of FGFR-1 transfected cells	technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2-4 μg/mL using trypsin-digested, human tissue sections, western blot: 0.25-0.5 μg/mL using extracts/lysates of FGFR-2 transfected cells
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Storage Class

12 - Non Combustible Liquids

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.