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Flecainide acetate salt

Name: Flecainide acetate salt
Brand: SIGMA

≥98% (HPLC), powder, sodium channel blocker

Synonym(s):

N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₀F₆N₂O₃ · C₂H₄O₂

CAS Number:

54143-56-5

Molecular Weight:

474.39

NACRES:

NA.77

PubChem Substance ID:

24278440

UNSPSC Code:

12352200

EC Number:

258-997-5

MDL number:

MFCD00214290

Quality level:

200

Pricing and availability is not currently available.

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Properties

Product Name

Flecainide acetate salt,

Quality Level

200

originator

Medicis

storage temp.

2-8°C

SMILES string

CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2

InChI

1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)

InChI key

RKXNZRPQSOPPRN-UHFFFAOYSA-N

Gene Information

human ... SCN5A(6331)

Description

Biochem/physiol Actions

Class IC antiarrhythmic agent; sodium channel blocker

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Medicis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	F0120000	1270800	Y0001274
Sigma-Aldrich F6777 Flecainide acetate salt	F0120000 Flecainide acetate	USP 1270800 Flecainide acetate	Y0001274 Flecainide for system suitability
Quality Level 200	Quality Level -	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
originator Medicis	originator -	originator -	originator -
Gene Information human ... SCN5A(6331)	Gene Information human ... SCN5A(6331)	Gene Information human ... SCN5A(6331)	Gene Information human ... SCN5A(6331)

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H315,H319,H335,H360FD

pcodes

P202 - P261 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Antiarrhythmic effects of flecainide.

P Somani

Clinical pharmacology and therapeutics, 27(4), 464-470 (1980-04-01)

A new class I antiarrhythmic, flecainide, was investigated in 10 patients to assess short-term efficacy and safety. All patients were hospitalized for 3 days; no antiarrhythmics were given on days 1 and 3. On day 2 flecainide 1 mg/kg was

Drug therapy. Flecainide.

D M Roden et al.

The New England journal of medicine, 315(1), 36-41 (1986-07-03)

[Severe flecainide acetate poisoning. Apropos of a case].

P Maury et al.

Archives des maladies du coeur et des vaisseaux, 92(2), 273-277 (1999-03-17)

Poisoning with flecainide acetate is rare and associated with a high mortality. This usually occurs after massive ingestion but can also be observed during therapeutic overdose in patients with renal failure or with amiodarone therapy. The prognostic depends on the