F8799
Fas/Fc Chimera from mouse
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Sinónimos:
Apo-1, CD95
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Servicio técnico
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Permítanos ayudarlerecombinant
expressed in baculovirus infected Sf21 cells
Quality Segment
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.03-0.1 μg per mL ED50 (in the presence of 20 ng/mL recombinant human Fas ligand for cytotoxicty assay of Jurkat cells)
mol wt
55 kDa (glycosylated form)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Fas(14102)
General description
Fas is a key component of apoptosis, and is a cell surface receptor. This gene is localized to human chromosome 10q24.1, and is composed of nine exons and eight introns.[1]
Application
Fas/Fc Chimera from mouse has been used as a blocking agent during FACS (flow cytometry).[2]
Biochem/physiol Actions
Fas and its ligand play an essential role in apoptosis, by activating the cell death signaling pathway. Mutations in this gene are associated with evasion of apoptosis by cells, leading to tumorigenesis, and prevention of clearance of these cells by the immune system.[1] A polymorphism in this gene results in the production of soluble Fas (sFas), which is implicated in the chronic autoimmune disorder called primary Sjögren′s syndrome (pSS).[3]
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 50 μg bovine serum albumin per 1 μg of cytokine.
Analysis Note
Biological activity was measured by its ability to inhibit Fas-ligand induced apoptosis of Jurkat cells.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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