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F9507

Flumethasone

Synonym(s):

6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone

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Pack SizeSKUAvailabilityPrice
50 mg
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$196.00
$147.00

About This Item

Empirical Formula (Hill Notation):
C22H28F2O5
CAS Number:
2135-17-3
Molecular Weight:
410.45
NACRES:
NA.85
PubChem Substance ID:
24894998
UNSPSC Code:
51102829
EC Number:
218-370-9
MDL number:
MFCD00056464

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form

powder

Quality Level

200

color

white to off-white

solubility

acetic acid: 10 mg/mL

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

WXURHACBFYSXBI-GQKYHHCASA-N

Application

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice[1] and has been used in cortisol assays to study early porcine conceptus development[2].

Biochem/physiol Actions

Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding .

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
D1756D18811275009
Flumethasone

Sigma-Aldrich

F9507

Flumethasone

Dexamethasone ≥98% (HPLC), powder

Sigma-Aldrich

D1756

Dexamethasone

Dexamethasone 21-acetate ≥99%

Sigma-Aldrich

D1881

Dexamethasone 21-acetate

Fluocinolone acetonide United States Pharmacopeia (USP) Reference Standard

USP

1275009

Fluocinolone acetonide

mode of action

cell membrane | interferes

mode of action

-

mode of action

-

mode of action

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

form

powder

form

powder

form

powder

form

-

solubility

acetic acid: 10 mg/mL

solubility

methanol: 25 mg/mL

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

color

white to off-white

color

off-white

color

-

color

-

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000445533
0000445533
0000371461
0000318567
0000371461

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K Sternbauer et al.
Zentralblatt fur Veterinarmedizin. Reihe A, 45(6-7), 441-443 (1998-10-30)
The impact of one single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.) on insulin sensitivity was studied in calves. Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment. At 24 h after treatment, insulin-dependent glucose utilization was
Dariusz Bednarek et al.
Veterinary microbiology, 96(1), 53-67 (2003-10-01)
The aim of this paper was to compare the effect of flumethasone and meloxicam in combination with oxytetracycline on clinical and immunological parameters of calves suffering from enzootic bronchopneumonia. The study was performed on 30 Black-and-White Lowland Breed calves with
R Draisci et al.
Journal of chromatography. B, Biomedical sciences and applications, 753(2), 217-223 (2001-05-04)
A new method for the rapid extraction and unequivocal confirmation of two highly potent fluorinated synthetic corticosteroids, dexamethasone and its beta-epimer betamethasone, in bovine liver was developed. Flumethasone was used as internal standard. An extraction procedure using an accelerated solvent
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Global Trade Item Number

SKUGTIN
F9507-50MG04061833621790
F9507-500MG04061833621783

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