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Anti-Fatty Acid Synthase (C-terminal) antibody produced in rabbit

Name: Anti-Fatty Acid Synthase (C-terminal) antibody produced in rabbit
Brand: SIGMA
Price: 2645 ILS

1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FAS, Anti-FASN

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Size/SKU	Availability	Price
200 μL	Please contact Customer Service for Availability	₪2,645.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00283209

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

₪2,645.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 270 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

western blot: 0.5-1 μg/mL using lysates of Rat1 cells, western blot: 1-2 μg/mL using lysates of human HEK 293-T cells

UniProt accession no.

P49327

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FASN(2194)
mouse ... Fasn(14104)
rat ... Fasn(50671)

Description

General description

Fatty acid synthase (FAS, FASN) is a multifunctional protein, mainly involved in catalyzing the synthesis of palmitate from acetyl-CoA and malonyl CoA, in the presence of NADPH. In mammals, it is composed of two identical multifunctional polypeptides, in which three catalytic domains in the N-terminal section (β-ketoacyl synthase, malonyl/acetyl tansferase, and dehydrase) are separated by a core region of about 600 residues from four C-terminal domains (enoyl reductase, β-ketoacyl reductase, acyl carrier protein, and thioesterase).

Immunogen

synthetic peptide corresponding to amino acids 2497-2511 of human fatty acid synthase, conjugated to KLH via an N-terminal added lysine residue. The corresponding sequence is conserved in human, rat, and mouse.

Application

Anti-Fatty Acid Synthase (C-Terminal) antibody is suitable for western blot analysis at a concentration of 0.5-1μg/mL using lysates of Rat1 cells and 1-2μg/mL using lysates of human HEK 293-T cells.

Biochem/physiol Actions

FAS plays an essential role during embryogenesis and energy homeostasis in adult animals. It also acts as the carbon source for fatty acid synthesis. It has been shown to be overexpressed in various types of human cancer, including prostate, breast, ovary and others.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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1 of 1

This Item	HPA006461	L9918	T5452
Sigma-Aldrich F9679 Anti-Fatty Acid Synthase (C-terminal) antibody produced in rabbit	Sigma-Aldrich HPA006461 Anti-FASN antibody produced in rabbit	Sigma-Aldrich L9918 Anti-LRRK2 (C-terminal region) antibody produced in rabbit	Sigma-Aldrich T5452 Anti-TTP (C-terminal) antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
mol wt antigen 270 kDa	mol wt -	mol wt antigen ~240 kDa	mol wt antigen ~50 kDa
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
Gene Information human ... FASN(2194) mouse ... Fasn(14104) rat ... Fasn(50671)	Gene Information human ... FASN(2194)	Gene Information human ... LRRK2(120892) mouse ... Lrrk2(66725) rat ... Lrrk2(300160)	Gene Information human ... ZFP36(7538) mouse ... Zfp36(22695) rat ... Zfp36(79426)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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