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Anti-GATA1 antibody produced in rabbit

Name: Anti-GATA1 antibody produced in rabbit
Brand: SIGMA
Price: 595 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1

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Size/SKU	Availability	Price
0.2 mL	Check Cart for Availability	$595.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02096392

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$595.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 45 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

microarray: suitable, western blot: 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562

UniProt accession no.

P15976

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GATA1(2623)

Description

General description

GATA is an important cis-element factor in the haematopoietic lineage belongs to GATA-binding protein family. It was first identified in the analysis of globin gene promoters and enhancers. There are different types of GATA proteins: GATA-1, GATA-2, GATA-3. It is expressed in erythroid, mast, megakaryocytic lineages, multipotential progenitor cells and lines.

GATA-1 (ERYF1, GF-1, NF-1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells.

Immunogen

synthetic peptide corresponding to the C-terminal region of human GATA-1 (amino acids 394-413).

Application

Anti-GATA1 antibody produced in rabbit has been used in gel mobility shift assay and DNase I footprinting. It has also been used in confocal microscopy analysis.

Biochem/physiol Actions

GATA is a lineage-restricted transcription factor which plays a pivotal role in erythroid differentiation. It possesses potential binding sites in the regulatory sequences of all erythroid genes. GATA is expressed at higher levels during erythroid maturation. It is essential for terminal differentiation of erythrocytes and megakaryocytes and associated in vivo with the acetyl transferase p300/CBP. Mutation in GATA1 causes thrombocytopenia and abnormal platelet function.

GATA-binding factor 1 (GATA-1) is involved in blocking apoptosis of precursor cells and in controlling the balance between proliferation and cell cycle arrest.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA072785	HPA004342	HPA067583
Sigma-Aldrich G0290 Anti-GATA1 antibody produced in rabbit	Sigma-Aldrich HPA072785 Anti-GATAD1 antibody produced in rabbit	Sigma-Aldrich HPA004342 Anti-GSTA1 antibody produced in rabbit	Sigma-Aldrich HPA067583 Anti-GATA5 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
mol wt antigen 45 kDa	mol wt -	mol wt -	mol wt -
species reactivity human	species reactivity human	species reactivity human	species reactivity human

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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