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G0544

GR 103691

≥98% (HPLC), solid

Synonym(s):

4′-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide

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Size/SKUAvailabilityPrice
10 mg
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$206.00

About This Item

Empirical Formula (Hill Notation):
C30H35N3O3
CAS Number:
Molecular Weight:
485.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$206.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >5 mg/mL at 60 °C

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

COc1ccccc1N2CCN(CCCCNC(=O)c3ccc(cc3)-c4ccc(cc4)C(C)=O)CC2

InChI

1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35)

InChI key

JARNORYOPMINDY-UHFFFAOYSA-N

Gene Information

rat ... Htr1a(24473)

Application

GR 103691 has been used as a D3 receptor antagonist to test its:
  • inducing effect on prepulse inhibition (PPI)
  • suppressive effect of motor behavior in rats
  • inhibitory effect on chemotaxis in newly excysted juvenile C. sinensis (CsNEJs)

Biochem/physiol Actions

GR 103691 increases the monosynaptic “stretch” reflex (MSR) amplitude in mice by its potent D3 receptor antagonist functionality. It inhibits the PD 128,907 mediated γ-aminobutyric acid (GABA) release.
D3 dopamine receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

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This Item
W1895N8162SML0524
description

≥98% (HPLC), solid

description

≥98% (HPLC)

description

≥97% (HPLC), solid

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble >5 mg/mL at 60 °C

solubility

H2O: ≥10 mg/mL

solubility

DMSO: ~16 mg/mL, H2O: insoluble

solubility

DMSO: 5 mg/mL, clear

color

white

color

white to off-white

color

off-white

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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