G0639
Glybenclamide
≥99% (HPLC), ATP-sensitive K+ channels blocker,
Synonym(s):
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 g | Available to ship TODAYfromMILWAUKEE | $136.00 |
10 g | Available to ship TODAYfromMILWAUKEE | $251.00 |
About This Item
Product Name
Glybenclamide, ≥99% (HPLC)
Quality Segment
assay
≥99% (HPLC)
solubility
ethanol: 2 mg/mL, DMSO: soluble, H2O: insoluble
originator
Roche
storage temp.
2-8°C
SMILES string
COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InChI
1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
InChI key
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Gene Information
human ... ABCC8(6833), KCNH2(3757), KCNJ1(3758), KCNJ11(3767)
rat ... Kcnj1(24521)
Application
- as a positive control oral hypoglycemic drug to study the hypoglycemic effects of Chlorella in streptozotocin-induced diabetic mice
- as a K+ATP channel antagonist in canine with induced acute hypoxia
- as an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR) channel in fetal distal lung epithelial (FDLE) cells
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥99% (HPLC) | description British Pharmacopoeia (BP) Reference Standard | description meets USP testing specifications | description A sulfonylurea that selectively blocks ATP-sensitive K+ channels. |
| assay ≥99% (HPLC) | assay - | assay - | assay ≥98% (TLC) |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 10-30°C |
| solubility H2O: insoluble, DMSO: soluble, ethanol: 2 mg/mL | solubility - | solubility - | solubility ethanol: 5 mg/mL, DMSO: 25 mg/mL |
| originator Roche | originator - | originator - | originator - |
| Gene Information human ... ABCC8(6833), KCNH2(3757), KCNJ1(3758), KCNJ11(3767) | Gene Information human ... ABCC8(6833), KCNJ11(3767) | Gene Information human ... ABCC8(6833), KCNH2(3757), KCNJ11(3767) | Gene Information - |
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Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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