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G0668

GW2974

≥98% (HPLC), solid

Synonym(s):

N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine

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Size/SKUAvailabilityPrice
50 mg
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$274.00
250 mg
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$1,010.00

About This Item

Empirical Formula (Hill Notation):
C23H21N7
CAS Number:
Molecular Weight:
395.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$274.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: ≥20 mg/mL

originator

GlaxoSmithKline

SMILES string

CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI

1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)

InChI key

DYYZXRCFCVDSKD-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

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This Item
T2067PZ0142SML1410
description

≥98% (HPLC), solid

description

99% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

99% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

-

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: ≥20 mg/mL

solubility

H2O: insoluble, DMSO: soluble (at 26 mg/ml)

solubility

DMSO: >20 mg/mL

solubility

DMSO: 10 mg/mL, clear

color

yellow

color

-

color

yellow

color

white to beige

originator

GlaxoSmithKline

originator

-

originator

-

originator

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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