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Gliclazide

Name: Gliclazide
Brand: SIGMA
Price: 180 USD
Availability: InStock

powder, ≥98%

Synonym(s):

1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea

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Size/SKU	Availability	Price
5 g	Estimated to ship onSeptember 30, 2027fromMILWAUKEE	$180.00

About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₁N₃O₃S

CAS Number:

21187-98-4

Molecular Weight:

323.41

NACRES:

NA.77

PubChem Substance ID:

24895090

UNSPSC Code:

12352125

EC Number:

244-260-5

MDL number:

MFCD00409893

Assay:

≥98%

Form:

powder

$180.00

Estimated to ship onSeptember 30, 2027Details

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Properties

Quality Segment

200

assay

≥98%

form

powder

color

white

mp

163-169 °C (lit.)

solubility

methylene chloride: soluble

originator

Servier

SMILES string

Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2

InChI

1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)

InChI key

BOVGTQGAOIONJV-UHFFFAOYSA-N

Gene Information

human ... KCNJ1(3758)

Description

Application

Gliclazide has been used:

to study its antiglycative properties and to study its effects on the glycation of bovine serum albumin (BSA) structure
as a reference standard in solid-phase extraction (SPE) followed by instrumental analysis using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the quantification of water samples
to develop and validate a simple, sensitive, rapid, economic and isocratic high-performance liquid chromatography (HPLC) method for the determination of gliclazide

Used in the treatment of non-insulin dependent diabetes mellitus (NIDDM).

Biochem/physiol Actions

Gliclazide is Kir6.2/SUR1 channel inhibitor.

Oxidative modification of low-density lipoprotein (LDL) plays an important role in vascular dysfunction associated with diabetes mellitus. Gliclazide is a second-generation sulfonylurea with free-radical-scavenging activity. Incubation of human aortic smooth muscle cell (HASMC) with native human LDL (100 μg/mL) in the presence of increasing concentrations of gliclazide (1 to 10 μg/mL) resulted in a dose-dependent decrease in HASMC-mediated LDL oxidation. Exposure of HASMCs to gliclazide (1 to 10 μg/mL) and native LDL (100 μg/mL) also led to a dose-dependent decrease in oxidized LDL-induced human monocyte adhesion to HASMCs. In addition, incubation of HASMCs with gliclazide dramatically reduced the ability of oxidized LDL to stimulate the proliferation of these cells. Finally, treatment of HASMCs with gliclazide resulted in a marked decrease in oxidatively modified LDL-induced monocyte chemoattractant protein (MCP)-1 and human heat shock protein 70 (HSP 70) expression, both at the gene and protein levels. These results show that gliclazide, at concentrations in the therapeutic range (5 to 10 μg/mL), is effective in vitro in reducing vascular smooth muscle cell (VSMC) dysfunction induced by oxidatively modified LDL. Administration of gliclazide to type 2 diabetic patients could form part of the strategy for the prevention and management of diabetic cardiovascular diseases

Features and Benefits

This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Show Differences

1 of 1

This Item	BP368	G0326000	PHR1288
Sigma-Aldrich G2167 Gliclazide	BP368 Gliclazide	G0326000 Gliclazide	Supelco PHR1288 Gliclazide
description powder, ≥98%	description British Pharmacopoeia (BP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description Pharmaceutical Secondary Standard; Certified Reference Material
assay ≥98%	assay -	assay -	assay -
form powder	form crystalline powder	form -	form -
Quality Level 200	Quality Level -	Quality Level -	Quality Level 300
solubility methylene chloride: soluble	solubility -	solubility -	solubility -
color white	color -	color -	color -
originator Servier	originator -	originator -	originator -

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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