G3381
Geldanamycin from Streptomyces hygroscopicus
from Streptomyces hygroscopicus, ≥98% (HPLC), Nuclear hormone receptor inhibitor, powder
Synonym(s):
NSC 122750
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $780.00 $663.00 |
About This Item
$663.00
List Price$780.00Save 15%Available to ship TODAYDetails
Product Name
Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC), powder
sterility
non-sterile
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: soluble
antibiotic activity spectrum
neoplastics
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
InChI
1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChI key
QTQAWLPCGQOSGP-KSRBKZBZSA-N
General description
Biochem/physiol Actions
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description 1 mg/mL, from Streptomyces hygroscopicus | description ≥95% (HPLC), powder | description ≥95% (HPLC), powder |
| assay ≥98% (HPLC) | assay - | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| form powder | form DMSO solution | form powder | form powder |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: soluble | solubility - | solubility ethanol: 2 mM, DMSO: soluble | solubility DMSO: 7.5 mg/mL |
| color yellow to orange | color - | color off-white | color yellow |
Storage Class
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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