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Anti-GABA_A Receptor (α3 subunit) antibody produced in rabbit

Name: Anti-GABA<SUB>A</SUB> Receptor (α3 subunit) antibody produced in rabbit
Brand: SIGMA
Price: 320.45 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

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0.05 mL	Check Cart for Availability	$377.00 $320.45

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03455039

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry: 1:200 using Rat brain frozen sections, western blot: 1:200-1:300 using Rat brain membranes

UniProt accession no.

P20236

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GABRA3(2556)
mouse ... Gabra3(14396)
rat ... Gabra3(24947)

Description

General description

GABA_A and GABA_B receptors differ with regard to their ionic characteristics and pharmacological properties. The GABA_A receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

Immunogen

peptide corresponding to amino acid residues 1-15 of human GABA(A) receptor α3 subunit. Identical in rat and mouse. Highly conserved (14/15 residues) in bovine.

Application

Anti-GABA_A Receptor (α3 subunit) antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:200 using rat brain frozen sections and immunoblotting at 1:200-1:300 using rat brain membranes.

Biochem/physiol Actions

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABA_A and GABA_B. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α3 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	G9920	G4416	AV34981
Sigma-Aldrich G4291 Anti-GABA_A Receptor (α3 subunit) antibody produced in rabbit	Sigma-Aldrich G9920 Anti-GABA_B Receptor 2 antibody produced in rabbit	Sigma-Aldrich G4416 Anti-GABA_A Receptor (α1 subunit) antibody produced in rabbit	$Anti-GABRA3 (AB1) antibody produced in rabbit IgG fraction of antiserum$ Sigma-Aldrich AV34981 Anti-GABRA3 (AB1) antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description affinity isolated antibody	description IgG fraction of antiserum
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
species reactivity rat	species reactivity rat	species reactivity mouse, rat, human (predicted), bovine (predicted), chicken (predicted)	species reactivity mouse, guinea pig, horse, human, rabbit, dog, rat, bovine

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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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