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[D-Lys³]-GHRP-6

Name: [<SC>D</SC>-Lys<SUP>3</SUP>]-GHRP-6
Brand: SIGMA
Price: 250 USD
Availability: InStock

synthetic, lyophilized powder

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Synonym(s):

[His¹, D-Lys³, Lys⁶]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH₂, [D-Lys³]-Growth Hormone Releasing Peptide 6

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Size/SKU	Availability	Price
5 mg	Check Cart for Availability	$250.00

About This Item

NACRES:

NA.32

PubChem Substance ID:

329799930

UNSPSC Code:

12352209

MDL number:

MFCD00214665

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Properties

biological source

synthetic

Quality Segment

200

form

lyophilized powder

UniProt accession no.

P01286

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](N)Cc6c[nH]cn6)C(N)=O

InChI

1S/C49H63N13O6/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65)/t36-,39-,40+,41+,42+,43-/m0/s1

InChI key

MGSNWNLPMHXGDD-DFWOJPNQSA-N

Gene Information

human ... GHRH(2691)

Description

General description

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.

Application

[D-Lys³]-GHRP6 has been used-

to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells
for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio

[D-Lys3]-GHRP-6 has been used:

to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
as an antagonist of growth hormone secretagogue receptor (GHS-R)
as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)

Biochem/physiol Actions

[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca²⁺ and Na⁺ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.

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1 of 1

This Item	T1567	G7923	506350
Sigma-Aldrich G4535 [D-Lys³]-GHRP-6	Sigma-Aldrich T1567 Tertiapin-Q trifluoroacetate salt	Sigma-Aldrich G7923 GO-201 trifluoroacetate salt	Sigma-Aldrich 506350 Pam₃Cys-Ser-(Lys)₄, Hydrochloride
description synthetic, lyophilized powder	description ≥97% (HPLC)	description ≥95% (HPLC)	description -
biological source synthetic	biological source -	biological source -	biological source -
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized	form lyophilized	form lyophilized solid
UniProt accession no. P01286	UniProt accession no. -	UniProt accession no. -	UniProt accession no. -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Gene Information human ... GHRH(2691)	Gene Information human ... KCNJ1(3758) mouse ... KCNJ1(56379) rat ... KCNJ1(24521)	Gene Information -	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Key Documents

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[D-Lys³]-GHRP-6

synthetic, lyophilized powder

Select a Size

About This Item

$250.00

biological source

Quality Segment

form

UniProt accession no.

storage temp.

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

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[D-Lys3]-GHRP-6

synthetic, lyophilized powder

Select a Size

About This Item

G4535-5MG

$250.00

biological source

Quality Segment

form

UniProt accession no.

storage temp.

SMILES string

InChI

InChI key

Gene Information

General description

Application

Biochem/physiol Actions

Compare Similar Items

This Item

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

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[D-Lys³]-GHRP-6