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Monoclonal Anti-Gelsolin antibody produced in mouse

Name: Monoclonal Anti-Gelsolin antibody produced in mouse
Brand: SIGMA
Price: 469.2 USD
Availability: InStock

clone GS-2C4, ascites fluid

Synonym(s):

Gelsolin Detection Antibody, Mouse Anti-Gelsolin

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Size/SKU	Availability	Price
100 μL	Estimated to ship TODAYfromMILWAUKEE	$552.00 $469.20
0.2 mL	Estimated to ship TODAYfromMILWAUKEE	$727.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164595

Conjugate:

unconjugated

Clone:

GS-2C4, monoclonal

Application:

ARR, ELISA (i), IHC (f), IHC (p), WB

Citations:

$469.20

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

GS-2C4, monoclonal

contains

15 mM sodium azide

species reactivity

bovine, pig, human, rabbit

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using heat-induced antigen retrieval sections, immunohistochemistry (frozen sections): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:1,000 using human plasma

isotype

IgG1

UniProt accession no.

P06396

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSN(2934)

Description

General description

Gelsolin is an actin-severing protein found in mammalian cells and blood plasma. Has tumor suppressor activity in several cancer cell lines and in nude mice.

Monoclonal Anti-Gelsolin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Gelsolin (GSN) is encoded by the gene mapped to human chromosome 9q33.2. GSN is a calcium dependent actin binding protein. It has been shown to exist in at least two variant forms, cytoplasmic gelsolin and plasma gelsolin. Plasma gelsolin has also been called as brevin. GSN is characterized with six domains G1-G6 at N-terminal end, each domain contains Ca²⁺ binding site.

Immunogen

human plasma gelsolin.

Application

Monoclonal Anti-Gelsolin antibody produced in mouse has been used in immunoprecipitation and immunohistochemical staining.

Biochem/physiol Actions

Gelsolin (GSN) is a potent modulator of actin filament length and gelation. It binds to the plus′ ends of actin monomers and filaments, preventing monomer exchange. GSN plays a vital role in regulation of actin dynamics. Mutations in this gene cause familial amyloidosis Finnish type (FAF) characterized by cranial neuropathy and lattice corneal dystrophy. Plasma gelsolin is used as a biochemical marker for acute rheumatic carditis.

The antibody is specific for an epitope located on the 47 kDa peptide derived from a chymotryptic cleavage of gelsolin. The antibody reacts with plasma and cytoplasmic gelsolin. An additional application for this antibody is immunoaffinity chromatography, for purification of gelsolin, and for detection of gelsolin-actin complexes in cell extracts.

Other Notes

This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200750 Anti-Gelsolin antibody, Mouse Monoclonal
clone GS-2C4, purified from hybridoma cell culture

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200750	WH0002934M1	G3893
Sigma-Aldrich G4896 Monoclonal Anti-Gelsolin antibody produced in mouse	Sigma-Aldrich SAB4200750 Anti-Gelsolin antibody, Mouse Monoclonal	Sigma-Aldrich WH0002934M1 Monoclonal Anti-GSN antibody produced in mouse	Sigma-Aldrich G3893 Monoclonal Anti-Glial Fibrillary Acidic Protein (GFAP) antibody produced in mouse
description clone GS-2C4, ascites fluid	description clone GS-2C4, purified from hybridoma cell culture	description clone 3G5, purified immunoglobulin, buffered aqueous solution	description clone G-A-5, ascites fluid
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form ascites fluid
clone GS-2C4, monoclonal	clone GS-2C4, monoclonal	clone 3G5, monoclonal	clone G-A-5, monoclonal
species reactivity bovine, pig, human, rabbit	species reactivity rabbit, canine, human, mouse, monkey	species reactivity human	species reactivity rat, human, pig
Gene Information human ... GSN(2934)	Gene Information human ... GSN(2934)	Gene Information human ... GSN(2934)	Gene Information human ... GFAP(2670) rat ... Gfap(24387)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c