G5169
GGTI 298 trifluoroacetate salt hydrate
≥90% (HPLC), film
Synonym(s):
N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
250 μg | Check Cart for Availability | $135.00 |
About This Item
Quality Segment
assay
≥90% (HPLC)
form
film, lyophilized
impurities
<10% dimer
color
colorless
mp
99.5-100 °C
solubility
DMSO: >20 mg/mL
storage temp.
−20°C
SMILES string
OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2cccc3ccccc23
InChI
1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1
InChI key
WALKWJPZELDSKT-UFABNHQSSA-N
Gene Information
human ... PGGT1B(5229)
Application
- to study the anticancer effects of statins along with GGTI 298
- to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
- to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥90% (HPLC), film | description ≥98% (HPLC), solid | description A potent, cell-permeable, and selective inhibitor of GGTase I. | description A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). |
| assay ≥90% (HPLC) | assay ≥98% (HPLC) | assay ≥90% (HPLC) | assay ≥95% (HPLC) |
| form film, lyophilized | form solid | form solid (Glassy) | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >20 mg/mL | solubility H2O: insoluble, DMSO: 25 mg/mL | solubility DMSO: 10 mg/mL | solubility DMSO: 200 mg/mL |
| color colorless | color white to beige | color - | color off-white |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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