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G5642

Monosialoganglioside GM₃

from canine blood, ≥98%, epidermal cell growth inhibitor, lyophilized powder

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0.5 mg

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$540.00
1 mg
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About This Item

CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98%
Form:
lyophilized powder

$540.00

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Product Name

Monosialoganglioside GM3 from canine blood, ≥98%, lyophilized powder

Quality Segment

assay

≥98%

form

lyophilized powder

solubility

chloroform/methanol/water (9.5:9.5:1): 20 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Application

Monosialoganglioside GM3 from canine blood has been used as a reference standard in high-performance thin-layer chromatography (HPTLC) to analyze ganglioside signatures of prostate cancer (CaP) cells. It has also been used to determine ganglioside-binding profiles of methylotrophic yeast (Pichia pastoris) secreted cholera toxin B subunit (PpCTB) by enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Monosialoganglioside GM3 has a potential role in cancer development and progression. Increased expression of GM3 has been observed in various types of cancer. Hence, it is used as a tumor-associated carbohydrate antigen during cancer vaccine development.
Monosialoganglioside-GM3 is the most common ganglioside and the major ganglioside in non-neuronal cell membranes. It inhibits epidermal cell growth and is involved in the biosynthesis and metabolism of all higher gangliosides.

Analysis Note

The product is soluble at 20 mg/mL in a 1:1 mixture of chloroform and ethanol with 5% water. The resulting solution is colorless

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This Item
G3018G3767G2392
description

≥98%, lyophilized powder

description

~98%, lyophilized powder

description

lyophilized powder, ≥96% (TLC)

description

≥95% (TLC), lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

assay

≥98%

assay

~98%

assay

≥96% (TLC)

assay

≥95% (TLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

chloroform/methanol/water (9.5:9.5:1): 20 mg/mL, clear, colorless to light yellow

solubility

-

solubility

DMSO: soluble, ethanol: soluble

solubility

DMSO: soluble


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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