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Anti-phospho-Glycogen Synthase Kinase 3α/β (pTyr^279/216) antibody produced in rabbit

Name: Anti-phospho-Glycogen Synthase Kinase 3α/β (pTyr<SUP>279/216</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 845 USD
Availability: InStock

affinity isolated antibody, aqueous glycerol solution

Synonym(s):

Anti-phospho-GSK α/β (pTyr^279/216)

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Size/SKU	Availability	Price
50 μg	Check Cart for Availability	$845.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD03455745

Conjugate:

unconjugated

Clone:

polyclonal

Application:

DB, ELISA (i), WB

Citations:

$845.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

aqueous glycerol solution

mol wt

antigen 47-51 kDa

species reactivity

human, mouse, rat

technique(s)

dot blot: suitable, indirect ELISA: suitable, western blot: 1:1000 using MCF-7 cell extract

UniProt accession no.

P49840

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr279/pTyr216)

Gene Information

human ... GSK3A(2931)
mouse ... Gsk3a(606496)
rat ... Gsk3a(50686)

Description

General description

GSK-3 functions a serine-threonine kinase and modulates a wide range of cellular activities such as cell signaling, cell cycle, cell growth and differentiation. Mammalian GSK-3 has two isoforms, namely, GSK-3α and GSK-3 β. GSK-3α has been implicated in Alzheimer′s disease, whereas both, GSK-3α and GSK-3β have been implicated in leukemia . Anti-phospho-Glycogen Synthase Kinase 3α/β (p(Tyr279/216)) antibody is specific for phosphorylated forms of GSK-3α (51 kDa) and GSK-3β (47 kDa) that contain a phosphate moiety on tyrosine 279 and 216 respectively. The antibody does not bind to non-tyrosine phosphorylated GSK-3α/β protein. The product recognizes human, mouse and rat GSK-3α/β.

Immunogen

synthetic phosphopeptide derived from the regions of GSK-3α/β that contain tyrosine^279/216.

Application

Anti-phospho-Glycogen Synthase Kinase 3α/β (p(Tyr279/216)) antibody is suitable for use in indirect ELISA, dot blot and western blot (1:1000 using MCF-7 cell extract).

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free), and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	ST1013	SAB4300237	SAB6010071
Sigma-Aldrich G5791 Anti-phospho-Glycogen Synthase Kinase 3α/β (pTyr^279/216) antibody produced in rabbit	Sigma-Aldrich ST1013 PhosphoDetect Anti-GSK-3α/β (pTyr^279/216) Rabbit pAb	Sigma-Aldrich SAB4300237 Anti-phospho-GSK3B (pTyr²¹⁶) antibody produced in rabbit	Sigma-Aldrich SAB6010071 Anti-phospho-GSK3A/GSK3B (Y216 + Y279) antibody, clone 4A5, Rabbit Monoclonal
description affinity isolated antibody, aqueous glycerol solution	description -	description affinity isolated antibody	description recombinant, expressed in HEK293F cells
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source -	biological source rabbit	biological source -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form -	antibody form affinity isolated antibody	antibody form -
species reactivity human, mouse, rat	species reactivity -	species reactivity rat, mouse, human	species reactivity human
technique(s) indirect ELISA: suitable, dot blot: suitable, western blot: 1:1000 using MCF-7 cell extract	technique(s) -	technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000, indirect immunofluorescence: 1:100-1:200	technique(s) flow cytometry: 1:50-1:200, ELISA: 2000:10000, immunohistochemistry: 1:50-1:200, immunofluorescence: 1:50-1:200

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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