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Anti-GSDMD (126-138) antibody produced in rabbit

Name: Anti-GSDMD (126-138) antibody produced in rabbit
Brand: SIGMA
Price: 185 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Gasdermin D Antibody, Gasdermin D Antibody - Anti-GSDMD (126-138) antibody produced in rabbit, Gsdmd Antibody, Anti-DF5L, Anti-FKSG10, Anti-GSDMDC1, Anti-Gasdermin domain-containing protein 1

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Size/SKU	Availability	Price
25 μL	Estimated to ship onSeptember 21, 2026fromMILWAUKEE	$185.00
200 μL	Estimated to ship onSeptember 21, 2026fromMILWAUKEE	$551.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

—

Citations:

$185.00

Estimated to ship onSeptember 21, 2026Details

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

immunoblotting: 1:250-1:500 using human HEK-293T cells over-expressing human recombinant. GSDMDC1.

UniProt accession no.

P57764

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSDMD(79792)

Description

General description

Gasdermin D (GSDMD) is also known as DFNA5L or gasdermin domain-containing 1 (GSDMDC1), belongs to the gasdermin protein family of epithelial proliferation regulators. GSDMD is expressed in upper gastrointestinal epithelium differentiating cells.

Immunogen

synthetic peptide corresponding to amino acids 126-138 of human GSDMD

Application

Anti-GSDMD (126-138) antibody produced in rabbit has been used in:

immunoblotting
CASP4/11 assay
cytokine enzyme?linked immunosorbent assay

Anti-GSDMD antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

GSDMD (gasdermin D) have been suggested to function in the regulation of epithelial apoptosis. GSDMD is expressed in differentiating cells. It may act as a tumor suppressor.

The absence of Gasdermin D (GSDMD), completely blocked LPS electroporation-triggered pyroptosis in studies performed on GSDMD siRNA knockdown or GSDMD knockout (both human HeLa cells and iBMDM mouse cells). It was also reported that caspase-4/11 specifically cleaves GSDMD after Asp275, results in gasdermin-N domain that bears intrinsic pyroptosis inducing activity. Furthermore, GSDMD-mediated pyroptosis participates in mature interleukin 1β (IL-1β) release without distressing its maturation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	WH0079792M1	H5912	SAB1307178
$Anti-GSDMD (126-138) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich G7422 Anti-GSDMD (126-138) antibody produced in rabbit	Sigma-Aldrich WH0079792M1 Monoclonal Anti-GSDMDC1 antibody produced in mouse	$Anti-phospho-Histone H2AX (pSer139) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich H5912 Anti-phospho-Histone H2AX (pSer¹³⁹) antibody produced in rabbit	Sigma-Aldrich SAB1307178 ANTI-GSDMA(N-TERMINAL) antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description clone 3F12-1B2, purified immunoglobulin, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
clone polyclonal	clone 3F12-1B2, monoclonal	clone polyclonal	clone polyclonal
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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