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Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit

Name: Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit
Brand: SIGMA
Price: 587 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GluN1, Anti-MRD8, Anti-NDHMSD, Anti-NDHMSR, Anti-NMD-R1, Anti-NMDA1, Anti-NMDAR1, Anti-NR1

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$587.00

About This Item

MDL number:

MFCD00282329

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$587.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 116 kDa

species reactivity

rat, human, mouse

packaging

antibody small pack of 25 μL

technique(s)

western blot: 1:2,000 using extract of a rat brain synaptosomal fraction.

UniProt accession no.

Q05586

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)

Description

General description

N-methyl-D-aspartate receptors (NMDAR1) is mainly expressed in mammalian brain. The gene is located on human chromosome 9q34.3.

NMDAR1 is a subunit of N-methyl D-aspartate (NMDA) receptor which is a subtype of glutamate-gated ion channels with high calcium permeability. NMDA receptors have unique voltage-dependent sensitivity to magnesium and are modified by glycine. It has a pivotal role in neuronal development, pathogenesis of acute and chronic neurodegenerative disorders, synaptic plasticity as well as memory acquisition and learning. Anti-glutamate receptor NMDAR1 (NR1) antibody can be used for studying the expression and function of NMDAR1 in different cell types and tissues as well as to compare its expression pattern with physiological functions or pathological conditions. Rabbit anti-glutamate receptor NMDAR1 (NR1) antibody reacts specifically with NMDAR1 (116kD) derived from rat brain.

Immunogen

synthetic peptide corresponding to the C-terminal region of rat NMDAR1 (amino acids 918-938). This sequence is identical in mouse NR1, human NR1 (short and long forms), and rat NR1 isoforms NR1b, NR1c, and NR1f.

Application

Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit has been used in endogenous calmodulin co-immunoprecipitation and immunoprecipitation.

Anti-glutamate receptor NMDAR1 (NR1) antibody can be used as a primary antibody in western blotting. It can also be used to identify NR1 from rat brain synaptosomal fraction by using immunoblotting.

Biochem/physiol Actions

N-methyl-D-aspartate receptor1 (NMDAR1) regulates excitatory synaptic transmission. Abnormal functioning of this receptor is associated with epilepsy and schizophrenia.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	AB9864R	ABN99	MAB1586
Sigma-Aldrich G8913 Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit	Sigma-Aldrich AB9864R Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal	Sigma-Aldrich ABN99 Anti-phospho NR1 (Ser897) Antibody	Sigma-Aldrich MAB1586 Anti-NMDAR1 Antibody, (all splice variants), clone R1JHL
description affinity isolated antibody, buffered aqueous solution	description clone 1.17.2.6, from rabbit, unconjugated	description from rabbit, purified by affinity chromatography	description clone R1JHL, Chemicon^®, from mouse
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
form buffered aqueous solution	form -	form -	form -
species reactivity rat, human, mouse	species reactivity rat, mouse	species reactivity rat	species reactivity mouse, rat, human

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