Key Documents

Anti-GRP78/BiP (GL-19) antibody produced in rabbit

Name: Anti-GRP78/BiP (GL-19) antibody produced in rabbit
Brand: SIGMA
Price: 605 USD
Availability: InStock

Enhanced Validation

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-78-kDa Glucose-Regulated Protein, Anti-Immunoglobulin Heavy Chain Binding Protein

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$605.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01865530

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, ICC, WB

Citations:

$605.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 78 kDa

species reactivity

mouse, hamster, human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells, microarray: suitable, western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract

UniProt accession no.

P11021

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HSPA5(3309)
mouse ... Hspa5(14828)

Description

General description

GRP78/BiP is a Ca²⁺-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.

Application

Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:

western blotting
immunocytochemistry
immunohistochemistry

Biochem/physiol Actions

GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca²⁺ ionophores, inhibition of the ER Ca²⁺ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca²⁺homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	G9043	M2694	MABS474
$Anti-GRP78/BiP (GL-19) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich G8918 Anti-GRP78/BiP (GL-19) antibody produced in rabbit	$Anti-GRP78/BiP (ET-21) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich G9043 Anti-GRP78/BiP (ET-21) antibody produced in rabbit	$Anti-Munc-18-1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich M2694 Anti-Munc-18-1 antibody produced in rabbit	Sigma-Aldrich MABS474 Anti-GRP78 Antibody, clone N88
description IgG fraction of antiserum, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description clone N88, from mouse
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone polyclonal	clone polyclonal	clone N88, monoclonal
mol wt antigen 78 kDa	mol wt antigen 78 kDa	mol wt antigen 67 kDa	mol wt -

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c