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Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit

Name: Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit
Brand: SIGMA
Price: 685 USD
Availability: InStock

affinity isolated antibody, buffered aqueous glycerol solution

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0.1 mL	Check Cart for Availability	$685.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01633637

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (f), WB

Citations:

$685.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

mouse, feline, rat

technique(s)

immunohistochemistry (frozen sections): 1:500, western blot: 1:1,000

UniProt accession no.

P23385

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Grm1(14816)
rat ... Grm1(24414)

Description

General description

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

Immunogen

synthetic peptide corresponding to the sequence of amino acids 1116-1130 of rat metabotropic glutamate receptor 1A (mGluR1a).

Application

Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000.

Biochem/physiol Actions

Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Mutations in this gene causes autosomal-recessive congenital cerebellar ataxia.

This antibody does not react with other splice variants or mGluR5.

Physical form

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0002911M2	AB9448	AB9213
Sigma-Aldrich G9665 Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit	Sigma-Aldrich WH0002911M2 Monoclonal Anti-GRM1 antibody produced in mouse	Sigma-Aldrich AB9448 Anti-Metabotropic Glutamate Receptor 1 Antibody	Sigma-Aldrich AB9213 Anti-Metabotropic Glutamate Receptor 7 Antibody
description affinity isolated antibody, buffered aqueous glycerol solution	description clone 1F7, purified immunoglobulin, buffered aqueous solution	description Chemicon^®, from rabbit	description Chemicon^®, from rabbit
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity purified immunoglobulin	antibody form affinity purified immunoglobulin
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
technique(s) western blot: 1:1,000, immunohistochemistry (frozen sections): 1:500	technique(s) western blot: 1-5 μg/mL, indirect ELISA: suitable	technique(s) immunohistochemistry: suitable (paraffin)	technique(s) western blot: suitable, immunohistochemistry: suitable (paraffin)
storage temp. −20°C	storage temp. −20°C	storage temp. -	storage temp. -

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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