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H1792

Hyperforin (dicyclohexylammonium) salt

≥98% (HPLC), monoamine reuptake inhibitor, powder

Synonym(s):

Hyp-DCHA, Hyperforin-DCHA

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$403.00

About This Item

Empirical Formula (Hill Notation):
C35H52O4·C12H23N
CAS Number:
238074-03-8
Molecular Weight:
718.10
UNSPSC Code:
12352200
PubChem Substance ID:
329815179
NACRES:
NA.25
MDL number:
MFCD04000098
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light

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Product Name

Hyperforin (dicyclohexylammonium) salt,

assay

≥98% (HPLC)

Quality Segment

form

powder

storage condition

protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

−20°C

SMILES string

C1CCC(CC1)NC2CCCCC2.CC(C)C(=O)[C@@]34C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(\C)C)(C[C@H](C\C=C(/C)C)[C@@]3(C)CC\C=C(\C)C)C4=O

InChI

1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1

InChI key

ZUYCAROZOLUHJY-DNSWOBEMSA-N

Biochem/physiol Actions

Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort.
Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found it to have neuroprotective effects against Alzheimer′s disease (AD) neuropathology, including the ability to disassemble amyloid-β aggregates in vitro and improve spatial memory in vivo.
Stable salt of hyperforin.
Stable salt of hyperforin. Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.

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This Item
PHL89225H5160H9791
Hyperforin (dicyclohexylammonium) salt

Sigma-Aldrich

H1792

Hyperforin (dicyclohexylammonium) salt

Hyperforin (stable Dicyclohexylammonium salt) phyproof® Reference Substance

PHL89225

Hyperforin (stable Dicyclohexylammonium salt)

Hyperforin ≥85% (HPLC)

Sigma-Aldrich

H5160

Hyperforin

Hyp9

Sigma-Aldrich

H9791

Hyp9

description

-

description

phyproof® Reference Substance

description

≥85% (HPLC)

description

-

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥85% (HPLC)

assay

≥98% (HPLC)

form

powder

form

-

form

solution

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: ≥10 mg/mL

solubility

-

solubility

-

solubility

DMSO: >20 mg/mL

storage condition

protect from light

storage condition

-

storage condition

-

storage condition

-

Signal Word

Danger

Hazard Codes

H302,H314,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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