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H2380

6-Hydroxy-DL-DOPA

≥98% (HPLC), powder, APE1 inhibitor

Synonym(s):

2,4,5-Trihydroxy-DL-phenylalanine, 2,5-Dihydroxy-DL-tyrosine

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Size/SKUAvailabilityPrice
5 mg
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$335.00
10 mg
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$642.00
100 mg
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$4,490.00

About This Item

Empirical Formula (Hill Notation):
C9H11NO5
CAS Number:
Molecular Weight:
213.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
2860065
Assay:
≥98% (HPLC)
Form:
powder

$335.00


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Product Name

6-Hydroxy-DL-DOPA, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: 3 mg/mL, 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)

storage temp.

−20°C

SMILES string

NC(Cc1cc(O)c(O)cc1O)C(O)=O

InChI

1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)

InChI key

YLKRUSPZOTYMAT-UHFFFAOYSA-N

General description

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared and protected from exposure to light.

Biochem/physiol Actions

6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.
Precursor 6-hydroxydopamine.
Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Hygroscopic; photosensitive

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This Item
P9003
description

≥98% (HPLC), powder

description

mol wt 1,000-5,000

assay

≥98% (HPLC)

assay

-

form

powder

form

powder

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

solubility

1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.), H2O: 3 mg/mL

solubility

-

color

off-white

color

white to off-white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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