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H3167

(2S,3S)-Hydroxybupropion hydrochloride

≥98% (HPLC), DAT and NET inhibitor, powder

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Synonym(s):

(2S,3S)-Hydroxybupropion hydrochloride, (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, (2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, GW 353162, Radafaxine hydrochloride, SS-hydroxybupropion hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$165.00
25 mg

Available to ship TODAYfromMILWAUKEE

$653.00
$555.05

About This Item

Empirical Formula (Hill Notation):
C13H18ClNO2 · HCl
CAS Number:
Molecular Weight:
292.20
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Product Name

(2S,3S)-Hydroxybupropion hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥12 mg/mL

storage temp.

−20°C

SMILES string

Cl.C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2

InChI

1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1

InChI key

ORXTVTDGPVINDN-BTJVGWIPSA-N

General description

(2S,3S)-hydroxybupropion is a major metabolite of bupropion.

Biochem/physiol Actions

(2S,3S)-hydroxybupropion is a dopamine transporter (DAT) and norepinephrine transporter (NET) transporters inhibitor and nicotinic acetylcholine receptor (nAChR) family modulator. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML0752E2750A6476
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98%

description

powder, ≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

assay

≥98% (HPLC)

form

powder

form

powder

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

DMSO: ≥12 mg/mL

solubility

H2O: 15 mg/mL, clear

solubility

-

solubility

H2O: soluble 15 mg/mL

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

desiccated


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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