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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Check Cart for Availability | $165.00 |
500 mg | Check Cart for Availability | $633.00 |
1 g | Check Cart for Availability | $970.00 |
About This Item
Linear Formula:
(HO)3C6H2CH2CH2NH2 · HCl
CAS Number:
Molecular Weight:
205.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
248-837-2
MDL number:
Beilstein/REAXYS Number:
4274007
eCl@ss:
32150312
Assay:
≥97% (titration)
Form:
powder
Product Name
6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
Quality Segment
assay
≥97% (titration)
form
powder
color
off-white to brown
mp
232-233 °C (dec.) (lit.)
solubility
H2O: >50 mg/mL, clear, yellow to brown
storage temp.
room temp
SMILES string
Cl.NCCc1cc(O)c(O)cc1O
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChI key
QLMRJHFAGVFUAC-UHFFFAOYSA-N
General description
6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Application
6-hydroxydopamine hydrochloride has been used:
- to induce Parkinson′s disease (PD) in rats
- to analyse cytotoxic effect of 6-OHDA on PC12 cell line
- to induce noradrenergic (NA) neuron deletion from the locus-coeruleus
Biochem/physiol Actions
Neurotoxin that destroys catecholaminergic terminals.
Preparation Note
Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.
Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.
Disclaimer
Hygroscopic
1 of 1
This Item | |||
|---|---|---|---|
| description ≥97% (titration), powder | description 95% | description 97% | description 99% (GC) |
| form powder | form powder | form - | form powder |
| assay ≥97% (titration) | assay 95% | assay 97% | assay 99% (GC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. room temp | storage temp. −20°C | storage temp. - | storage temp. - |
| solubility H2O: >50 mg/mL, clear, yellow to brown | solubility - | solubility - | solubility - |
| color off-white to brown | color - | color - | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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