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H5160

Hyperforin

≥85% (HPLC), Use secondary activity, solution

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Size/SKUAvailabilityPrice
250 μg

Available to ship TODAYfromMILWAUKEE

$335.00

About This Item

Empirical Formula (Hill Notation):
C35H52O4
CAS Number:
Molecular Weight:
536.78
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-659-6
MDL number:
Assay:
≥85% (HPLC)
Form:
solution

$335.00


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Product Name

Hyperforin, ≥85% (HPLC)

Quality Segment

assay

≥85% (HPLC)

form

solution

storage temp.

−20°C

SMILES string

CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O

InChI

1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1

InChI key

IWBJJCOKGLUQIZ-HQKKAZOISA-N

General description

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

Application

Hyperforin may be used:
  • as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
  • to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
  • as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

Biochem/physiol Actions

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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storage temp.

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storage temp.

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storage temp.

2-8°C


Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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