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Anti-phospho-Histone H2AX (pSer¹³⁹) antibody produced in rabbit

Name: Anti-phospho-Histone H2AX (pSer<SUP>139</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 725 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

H2Ax Antibody, H2Ax Antibody - Anti-phospho-Histone H2AX (pSer139) antibody produced in rabbit, Anti-H2AXS139p

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$725.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

MDL number:

MFCD04974783

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$725.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 15 kDa

species reactivity

mouse, human

technique(s)

microarray: suitable, western blot: 1:1,000 using whole cell extracts of HeLa (human epitheloid carcinoma) cells or NIH3T3 mouse fibroblast cells treated with staurosporine

UniProt accession no.

P16104

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer139)

Gene Information

human ... H2AFX(3014)
mouse ... H2afx(15270)

Description

General description

H2AX comprises 2-25% of the total H2A complement in human cells, whereas in the budding yeast it constitutes virtually all of the H2A molecules. It has N-terminal and C-terminal region with a central globular domain. The C-terminal region has sites for modification including acetylation, biotinylation and phosphorylation.

Immunogen

The synthetic peptide sequence is conjugated to KLH. The immunogen sequence is highly conserved (single amino acid substitution) in mouse histone H2AX.

synthetic phosphorylated peptide corresponding to the C-terminus (amino acids 134-142) of human histone H2AX (pSer¹³⁹).

Application

Anti-phospho-Histone H2AX (pSer139) antibody produced in rabbit has been used in immunofluorescence and western blotting.

Biochem/physiol Actions

H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA. Ataxia-telangiectasia-mutated (ATM) is the major kinase involved in the phosphorylation of H2AX in response to DNA double-strand breaks. H2AX knockout mice are radiation sensitive and show retarted growth. They also are immune deficient with mutant males are infertile..

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4504428	SAB4300213	SAB5701787
$Anti-phospho-Histone H2AX (pSer139) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich H5912 Anti-phospho-Histone H2AX (pSer¹³⁹) antibody produced in rabbit	Sigma-Aldrich SAB4504428 Anti-phospho-Histone H2A.X (pSer¹³⁹) antibody produced in rabbit	Sigma-Aldrich SAB4300213 Anti-phospho-H2AFX (pSer¹³⁹) antibody produced in rabbit	Sigma-Aldrich SAB5701787 Anti-Phospho-Histone H2AX-S139 antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description affinity isolated antibody	description affinity isolated antibody	description -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form -
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form liquid
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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