H6660
HIV Protease Substrate 1
≥95% (HPLC), powder
Synonym(s):
Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Check Cart for Availability | $682.00 |
About This Item
$682.00
Check Cart for Availability
Product Name
HIV Protease Substrate 1,
assay
≥95% (HPLC)
Quality Segment
form
powder
mol wt
2016
solubility
DMSO: soluble
storage temp.
−20°C
Application
Biochem/physiol Actions
Substrate for endopeptidases
HIV Protease Substrate 1 is a synthetic peptide sequence that contains the cleavage site (Tyr-Pro) for the human immunodeficiency virus (HIV) Protease. It has two covalently modified amino acids for the detection of cleavage. One modification is the addition of the fluorophore 5-(2-aminoethylamino)-1-naphthalene sulfonate (EDANS) to the glutamic acid residue, while the other one includes the addition of the acceptor chromophore 4c-dimethylaminoazobenzene-4-carboxylate (DABCYL) to the lysine residue. The modified amino acids are on opposite sides of the cleavage site. Spatial orientation and overlap of the DABCYL absorbance with the EDANS emission permit resonance energy transfer between the two moieties. However, when the peptide is cleaved by the HIV protease, the DABCYL group is no longer proximal to the fluorophore.
1 of 1
This Item | |
|---|---|
| description - | description Ex: 320nm, Em: 420nm |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| solubility DMSO: soluble | solubility acetonitrile: water (1:4): 1 mg/mL |
| Quality Level 200 | Quality Level 200 |
| form powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C |
| mol wt 2016 | mol wt - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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