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H7017

Hemocyanin from Megathura crenulata (keyhole limpet)

Synonym(s):

KLH, Keyhole limpet hemocyanin

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20 mg

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$136.00
50 mg

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$291.00
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$527.00

About This Item

CAS Number:
9013-72-3
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131280
Form:
powder
Biological source:
Megathura crenulata

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biological source

Megathura crenulata

Quality Segment

form

powder

packaging

vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)

technique(s)

ELISA: suitable

solubility

H2O: soluble

storage temp.

2-8°C

General description

Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.

Application

Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response. Hemocyanins stimulate Th1 reactions without known side effects, which make them ideal for long-term continuous treatment of cancer.

Physical form

Lyophilized with stabilizing buffer

Preparation Note

Reconstitute with deionized water to a KLH concentration of 10 mg/mL, to yield an opalescent solution in 31 mM sodium phosphate buffer, pH 7.4, containing 0.46 M NaCl, 2% PVP and 41 mM sucrose.
Reconstituted protein solution may be stored up to 2 months at −20 °C.

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Hemocyanin from Megathura crenulata (keyhole limpet)

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Sigma-Aldrich

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Hemocyanin from mollusk

Lectin from Triticum vulgaris lyophilized, ≥55% (GE), powder

Sigma-Aldrich

61767

Lectin from Triticum vulgaris

description

-

description

PBS solution

description

buffered aqueous solution

description

lyophilized, ≥55% (GE), powder

biological source

Megathura crenulata

biological source

Megathura crenulata

biological source

Concholepas sp. (Concholepas concholepas )

biological source

Triticum vulgaris

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

bioconjugation: suitable

technique(s)

agglutination assay: suitable using fresh human erythrocytes

form

powder

form

PBS solution

form

buffered aqueous solution

form

powder

solubility

H2O: soluble

solubility

-

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

packaging

vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)

packaging

-

packaging

-

packaging

-

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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