The anticoagulant activity for H7640 is not determined during quality control testing. The testing that is performed is limited to appearance, solubility, Infrared Spectrum, Nitrogen and Sulfur only. There are heparin sodium salt products that do test for anticoagulant activity, Among the heparin sodium salt products that test for anticoagulant activity are H3393, H3149, H4784, H5515 and 2106.
H7640
Heparan sulfate sodium salt from bovine kidney
powder, extracellular matrix component
Synonym(s):
Heparitin sulfate sodium salt
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $221.00 |
5 mg | Available to ship TODAYfromMILWAUKEE | $773.00 |
10 mg | Check Cart for Availability | $1,360.00 |
About This Item
Application
Biochem/physiol Actions
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars. It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units. It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression. HS is associated with the onset of infectious diseases and inflammatory conditions. HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
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This Item | |||
|---|---|---|---|
| description - | description extent of labeling: 12-15 mol per mol β-CD | description ≥93% (TLC), powder | description from Porcine intestinal mucosa, ≥90%, lyophilized powder |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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Was the anticoagulant activity of this product determined? Is degree of contamination with heparin known?
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What solvent should i use to dissolve this?
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The solubility of this item is 1mg/ml as mentioned on the COA.
Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdfHelpful?
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Wo finde ich eine Angabe zum Molekulargewicht?
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The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.
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