This product is provided in solid form and will appear as an orange to orange-red powder.
I0404
Indirubin-3′-oxime
≥98% (HPLC), solid
Synonym(s):
Indirubin-3′-monoxime
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $212.00 $180.20 |
5 mg | Available to ship TODAYfromMILWAUKEE | $724.00 |
About This Item
Empirical Formula (Hill Notation):
C16H11N3O2
CAS Number:
Molecular Weight:
277.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
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Quality Segment
assay
≥98% (HPLC)
form
solid
mol wt
277.28
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
room temp
SMILES string
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4ccccc34
InChI
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
InChI key
HBDSHCUSXQATPO-BGBJRWHRSA-N
Application
Indirubin-3′-oxime has been used in the inhibition of glycogen synthase kinase 3 in human monocytic cell line, THP-1.
Biochem/physiol Actions
Indirubin-3′-oxime mediates apoptosis in Jurkat T cells and has anti-tumor functionality. Indirubin-3′-oxime inhibits Y box binding protein 1 (YB1) translocation, contributing to anticancer functionality. Indirubin-3′-oxime decreases expression of estrogen-related receptor γ (ERRγ) and peroxisome proliferator-activated receptor-γ co-activator-1α (PGC1α) in human neuroblastoma, leading to cell cycle arrest and mitochondrial dysfunction.
Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
Features and Benefits
This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description - | description ≥98% (HPLC), powder | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| mol wt 277.28 | mol wt - | mol wt - | mol wt - |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility DMSO: >10 mg/mL, H2O: insoluble | solubility DMSO: ≥20 mg/mL | solubility water: 10 mg/mL, clear | solubility DMSO: >10 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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