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IL-6 rat

Name: IL-6 rat
Brand: SIGMA
Price: 374 USD
Availability: InStock

>97% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Synonym(s):

Interleukin-6 from rat

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Size/SKU	Availability	Price
10 μg	Check Cart for Availability	$374.00
50 μg	Check Cart for Availability	$1,010.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD01323739

Biological source:

rat

Recombinant:

expressed in E. coli

Assay:

>97% (SDS-PAGE)

Form:

buffered aqueous solution

Mol wt:

predicted mol wt ~22 kDa

Impurities:

<0.01EU/mg (LAL test)

$374.00

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Properties

Product Name

Interleukin-6 from rat, IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

biological source

rat

Quality Segment

200

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

buffered aqueous solution

potency

0.01-0.06 ng/mL ED₅₀

quality

endotoxin tested

mol wt

predicted mol wt ~22 kDa

packaging

pkg of 10 and 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.01EU/mg (LAL test)

UniProt accession no.

P20607.1

shipped in

dry ice

storage temp.

−70°C

Description

Biochem/physiol Actions

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β₂), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM sodium acetate, pH 4, with BSA as a carrier protein.

Preparation Note

Recombinant, rat Interleukin-6 is produced from a DNA sequence encoding the mature rat IL-6 protein. The methionyl form of mature rat IL-6, a 188 amino acid protein, has a predicted molecular mass of approx. 22 kDa. Rat and mouse IL-6 share 93% amino acid sequence identity.

Analysis Note

The biological activity is measured in a cell proliferation assay using IL-6 dependent mouse plasmacytoma cell line, T1165.85.2.1.

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This Item	I9646	I3650	11138600001
Sigma-Aldrich I0406 Interleukin-6 from rat	Sigma-Aldrich I9646 Interleukin-6 from mouse	Sigma-Aldrich I3650 Interleukin-4 from rat	Roche 11138600001 Interleukin-6, human (hIL-6)
description IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture	description IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free	description recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)	description recombinant (E. coli)
assay >97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay >98% (SDS-PAGE)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
biological source rat	biological source mouse	biological source rat	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| hybridoma: suitable
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level -
form buffered aqueous solution	form lyophilized powder	form lyophilized powder	form solution

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Storage Class

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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