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Anti-IκBα antibody produced in rabbit

Name: Anti-IκBα antibody produced in rabbit
Brand: SIGMA
Price: 605 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-AUTSX3, Anti-MRX16, Anti-MRX79, Anti-MRXS13, Anti-MRXSL, Anti-PPMX, Anti-RS, Anti-RTS, Anti-RTT

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$605.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01092370

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$605.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

mouse, human, rat

technique(s)

microarray: suitable, western blot: 1:2,000 using a whole extract of human epidermal carcinoma A431 cells, western blot: 1:2,000 using a whole extract of human epitheloid carcinoma HeLa cells

UniProt accession no.

P25963

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NFKBIA(4792)
mouse ... Nfkbia(18035)
rat ... Nfkbia(25493)

Description

General description

The gene NFKBIA (nuclear factor of κ light polypeptide gene enhancer B-cells inhibitor-α) encodes the α member of the NF-κ-B inhibitor family IκB, which also consists of IκBβ and IκBε. NFKBIA is also referred to as IκBα. It is the strongest inhibitor of nuclear NF-κB activity among these members. Specific phosphorylation of the inhibitor IκBα at Ser32 and Ser36, its ubiubiquitination and subsequent proteolytic degradation is necessary for the activation of NF-κ-B. It is localized to the cytosol, where it retains NF-κB. Polymorphism in this gene is linked to recurrent acute rejections in liver transplant recipients. Mutations in this gene have been linked to autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. The gene NFKBIA is mapped to human chromosome 14q13.

Immunogen

synthetic peptide corresponding to the C-terminus of human IκBα (amino acids 297-317 with N-terminally added lysine) conjugated to KLH.

Application

Anti-IκBα antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Specific phosphorylation of the inhibitor IκBα at Ser32 and Ser36, its ubiquitination and subsequent proteolytic degradation is necessary for the activation of NF-κ-B. Polymorphism in this gene is linked to recurrent acute rejections in liver transplant recipients. Mutations in this gene have been linked to autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5700926	SAB4501995	SAB4501994
$Anti-IκBα antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich I0505 Anti-IκBα antibody produced in rabbit	Sigma-Aldrich SAB5700926 Anti- IκBα antibody produced in rabbit	Sigma-Aldrich SAB4501995 Anti-IκB-α antibody produced in rabbit	Sigma-Aldrich SAB4501994 Anti-IκB-α antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description -	description affinity isolated antibody	description affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form IgG fraction of antiserum	antibody form -	antibody form affinity isolated antibody	antibody form affinity isolated antibody
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
form buffered aqueous solution	form liquid	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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