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I100

5-Iodotubercidin

≥85%, solid

Synonym(s):

4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, 5-Iodotubericidin, 7-Iodo-7-deazaadenosine

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
€664.00
25 mg
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€2,600.00
€2,210.00

About This Item

Empirical Formula (Hill Notation):
C11H13IN4O4
CAS Number:
24386-93-4
Molecular Weight:
392.15
NACRES:
NA.77
PubChem Substance ID:
329815331
UNSPSC Code:
12352202
MDL number:
MFCD00055131
Assay:
≥85%
Form:
solid

€664.00

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Quality Segment

100

assay

≥85%

form

solid

storage temp.

2-8°C

SMILES string

Nc1ncnc2n(cc(I)c12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

InChI

1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1

InChI key

WHSIXKUPQCKWBY-IOSLPCCCSA-N

General description

5-Iodotubercidin is a purine and modulates cellular adenosine levels by inhibiting the functionality of adenosine kinase. It is an activator for p53 and favors tumor suppression and may serve as a potential chemotherapeutic agent. 5-Iodotubercidin mediated blockade of adenosine to adenosine monophosphate (AMP) conversion results in alleviating antinociceptive effect of AMP. 5-Iodotubercidin is under clinical trial testing for treating epilepsy.
solubility: 10 mg/mL in DMSO

Application

5-Iodotubercidin has been used for the inhibition of retinoblastoma cells, astroglial cultures and for the inhibition of adenosine kinase in human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

5-Iodotubercidin increases fatty acid oxidation activity and glycogen synthesis in hepatocytes. 5-Iodotubercidin is also a potent inhibitor of adenosine uptake into brain.
Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.

Disclaimer

Solutions may be stored frozen. Use promptly when thawed and protect from exposure to light.

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852597567809M33931
5-Iodotubercidin ≥85%, solid

Sigma-Aldrich

I100

5-Iodotubercidin

5-Iodouridine 95%

Sigma-Aldrich

852597

5-Iodouridine

Src Inhibitor, PP1 The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Millipore

567809M

Src Inhibitor, PP1

Clioquinol VETRANAL®, analytical standard

Supelco

33931

Clioquinol

description

≥85%, solid

description

95%

description

The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

VETRANAL®, analytical standard

assay

≥85%

assay

95%

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

form

solid

form

powder

form

solid

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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