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Anti-phospho-Insulin Receptor (IR) (pTyr⁹⁷²) antibody produced in rabbit

Name: Anti-phospho-Insulin Receptor (IR) (pTyr<SUP>972</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 966 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD05665246

Conjugate:

unconjugated

Clone:

polyclonal

Application:

—

Citations:

$966.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

UniProt accession no.

P14616

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

phosphorylation (pTyr972)

Gene Information

human ... INSRR(3645)
mouse ... Insr(16337)

Description

General description

The biological effects of insulin are mediated by insulin receptor (IR) and IGF-1 receptor. Insulin receptor consists of two α and two β subunits, each subunit has a tyrosine kinase domain. Signaling by IR is important in cell proliferation and metabolism of glucose. Insulin receptor activates the PI3K/Akt and the FKHR pathway, thereby regulates metabolism and insulin-dependent gene expression. Tyrosine 972 is an autophosphorylation site that is present in the juxtamembrane domain. Phosphorylation at Tyr972 is required for interaction of IR with its intracellular substrates and increases the stability of IR and substrate complexes. Overexpression of IR has been observed in breast cancer tissue and is implicated in proliferation of breast cancer cells, hyperinsulinemia and insulin resistance. IR can also bind IGF-I and IGF-II with decreased affinity
Anti-phospho-IR (pTyr⁹⁷²) recognizes human and mouse IR phosphorylated on tyrosine 972. It may cross react with IGF-1R.

Immunogen

phosphopeptide derived from the region of human insulin receptor (IR) that contains tyrosine 972.

Biochem/physiol Actions

This antibody may also have cross-reactivity with phosphosphorylated insulin-like growth factor-1 receptor (IGF-1R).

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, 50% glycerol with 1 mg/ml of bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4300652	HPA025285	407707
Sigma-Aldrich I1783 Anti-phospho-Insulin Receptor (IR) (pTyr⁹⁷²) antibody produced in rabbit	Sigma-Aldrich SAB4300652 Anti-phospho-IGF-1R (pTyr¹²⁸⁰) antibody produced in rabbit	Sigma-Aldrich HPA025285 Anti-INSRR antibody produced in rabbit	Sigma-Aldrich 407707 PhosphoDetect Anti-Insulin Receptor (pTyr^1162/1163) Rabbit pAb
description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description liquid, Calbiochem^®
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form -
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution	form liquid
UniProt accession no. P14616	UniProt accession no. -	UniProt accession no. P14616	UniProt accession no. -

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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