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I1911

IU1

≥98% (HPLC)

Synonym(s):

1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$157.00
$163.00

About This Item

Empirical Formula (Hill Notation):
C18H21FN2O
CAS Number:
314245-33-5
Molecular Weight:
300.37
NACRES:
NA.77
PubChem Substance ID:
329815361
UNSPSC Code:
12352200
MDL number:
MFCD01917473
Assay:
≥98% (HPLC)
Form:
powder

$163.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

FC1=CC=C(N2C(C)=CC(C(CN3CCCC3)=O)=C2C)C=C1

InChI

1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3

InChI key

JUWDSDKJBMFLHE-UHFFFAOYSA-N

Application

IU1 has been used for the inhibition of Ubiquitin Specific Peptidase 14 (USP14) in human neuroblastoma cells (SH-SY5Y) and in ubiquitin-rhodamine hydrolysis plate assay.

Biochem/physiol Actions

IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome.
IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. The proteasome mediates the cellular degradation of oxidized, damaged and misfolded proteins which, if not removed, accumulate and become toxic to cells. Proteins targeted for proteasomal degradation are first ubiquitinated, with longer length ubiquitin chains interacting more strongly with the proteasome. Deubiquitinating enzymes (DUBs) such as USP14 interfere with the degradation process. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

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This Item
SAB5701286HPA001308JRD1207
IU1 ≥98% (HPLC)

Sigma-Aldrich

I1911

IU1

Anti-USP14 antibody produced in rabbit

Sigma-Aldrich

SAB5701286

Anti-USP14 antibody produced in rabbit

Anti-USP14 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA001308

Anti-USP14 antibody produced in rabbit

1-(2,4-Difluorophenyl)-1H-pyrazole-4-carbonitrile AldrichCPR

JRD1207

1-(2,4-Difluorophenyl)-1H-pyrazole-4-carbonitrile

description

≥98% (HPLC)

description

-

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

AldrichCPR

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

liquid

form

buffered aqueous glycerol solution

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: >10 mg/mL

solubility

-

solubility

-

solubility

-

color

off-white to light brown

color

-

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

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