Skip to Content

Legal compliance reminder: purchasers must obtain all necessary licenses and comply with applicable laws (see General Terms & Conditions of Sale). We reserve the right to request additional information.

MilliporeSigma

Key Documents

View All Documentation

Skip To

I2286

Irbesartan

≥98% (HPLC), angiotensin II type 1 (AT1) receptor antagonist, powder

Promotion Available

Synonym(s):

2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, Avapro, BMS-186295, SR-47436

Sign In to View Organizational & Contract Pricing.

Spend $500 — Save 5%; Spend $800 — Save 10%; Spend $1,600 — Save 22%*

Sign in to check eligibility. Shop Products

Select a Size

Change View
Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$107.00
50 mg

Available to ship TODAYfromMILWAUKEE

$415.00

About This Item

Empirical Formula (Hill Notation):
C25H28N6O
CAS Number:
138402-11-6
Molecular Weight:
428.53
UNSPSC Code:
12352200
PubChem Substance ID:
329815365
NACRES:
NA.77
MDL number:
MFCD00864464
Assay:
≥98% (HPLC)
Form:
powder

$107.00

Save Up To 22%

Available to ship TODAYDetails

​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Irbesartan, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >25 mg/mL

originator

Bristol-Myers Squibb, Sanofi Aventis

storage temp.

2-8°C

SMILES string

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5

InChI

1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChI key

YOSHYTLCDANDAN-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

General description

Irbesartan comprises bipentyl-tetrazole side chain. It is an imidazole derivative with high bioavailability and is metabolized by the enzyme cytochrome P450 2C9 isoenzyme in liver to be majorly eliminated by oxidation and glucuronidation.

Application

Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue. It may be used to test its effect on allergic asthma in rat and mice mast cells.

Biochem/physiol Actions

Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity. It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties. Irbesartan shows protective cardiovascular effects and provides protection against chronic glomerulonephritis.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
PHR1443Y0001166BP1093
Irbesartan ≥98% (HPLC), powder

Sigma-Aldrich

I2286

Irbesartan

Irbesartan Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1443

Irbesartan

Irbesartan European Pharmacopoeia (EP) Reference Standard

Y0001166

Irbesartan

Irbesartan British Pharmacopoeia (BP) Reference Standard

BP1093

Irbesartan

description

≥98% (HPLC), powder

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

solid

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: >25 mg/mL

solubility

-

solubility

-

solubility

-

originator

Sanofi Aventis, Bristol-Myers Squibb

originator

-

originator

-

originator

-

Still not finding the right product?

Explore all of our products under Irbesartan

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000024964
0000426827
0000016548
0000024965
0000040729

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters