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I2526

Insulin-like Growth Factor-II human

IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IGF-II, Somatomedin A

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Size/SKUAvailabilityPrice
50 μg
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$327.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00241895
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
monomer 7.5 kDa ((67 aa))
Impurities:
≤0.1 EU/μg (LAL test)

$327.00

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biological source

human

Quality Segment

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

≤6 ng/mL ED50

quality

endotoxin tested

mol wt

monomer 7.5 kDa ((67 aa))

packaging

pkg of 5X50 μg, pkg of 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤0.1 EU/μg (LAL test)

UniProt accession no.

storage temp.

−20°C

Biochem/physiol Actions

IGF-II, also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. IGF-II binds to the IGF-II receptor, IGF-I receptor, and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-I receptor. However, during embryogenesis the roles of both IGF-II receptor and IR may be significant in promoting normal growth.
Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

Physical form

Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA).

Preparation Note

Reconstitute with sterile water at 0.1 mg/mL

Analysis Note

The biological activity is measured by a cell proliferation assay using Human breast cancer cell line MCF-7

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Insulin-like Growth Factor-II human IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

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Insulin-like Growth Factor-II human

Insulin-like Growth Factor-I human IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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I3769

Insulin-like Growth Factor-I human

Insulin-like Growth Factor-I Receptor human ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

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Insulin-like Growth Factor-I Receptor human

Insulin-like Growth Factor-II from mouse IGF-II, recombinant, expressed in E. coli, lyophilized powder

Sigma-Aldrich

I8904

Insulin-like Growth Factor-II from mouse

description

IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

description

IGF-II, recombinant, expressed in E. coli, lyophilized powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

assay

≥95% (HPLC)

assay

≥95% (SDS-PAGE)

assay

>97% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

mouse

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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