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Anti-Interleukin-1α antibody produced in goat

Name: Anti-Interleukin-1α antibody produced in goat
Brand: SIGMA
Price: 628 USD
Availability: InStock

IgG fraction of antiserum, lyophilized powder

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Synonym(s):

Anti-IL-1α

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Size/SKU	Availability	Price
1 mg	Available to ship TODAYfromMILWAUKEE	$628.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00165461

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), Neutral, WB

Citations:

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Properties

biological source

goat

Quality Segment

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: suitable, neutralization: suitable, western blot: suitable

UniProt accession no.

P01582

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Il1a(16175)

Description

General description

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with mouse IL-1α. It does not react with human IL-1α and IL-1β or mouse IL-1β.

Immunogen

recombinant mouse IL-1α.

Application

Anti-interleukin 1α antibody is suitable for neutralization reactions and the recommended ND50 is 0.04-0.2 μg/ml. The antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for indirect ELISA applications.

Biochem/physiol Actions

The antibody will neutralize the biological activity of recombinant mouse IL-1α, but not recombinant human IL-1α, IL-1β or recombinant mouse IL-1β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline pH 7.4, with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	I3767	I8909	I8273
$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I3392 Anti-Interleukin-1α antibody produced in goat	$Anti-Interleukin-1β antibody produced in goat IgG fraction of antiserum$ Sigma-Aldrich I3767 Anti-Interleukin-1β antibody produced in goat	$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8909 Anti-Interleukin-1α antibody produced in goat	$Anti-Interleukin-2 antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8273 Anti-Interleukin-2 antibody produced in goat
description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum	description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum, lyophilized powder
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum
biological source goat	biological source goat	biological source goat	biological source goat
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
Gene Information mouse ... Il1a(16175)	Gene Information mouse ... Il1b(16176)	Gene Information human ... IL1A(3552)	Gene Information human ... IL2(3558)
species reactivity mouse	species reactivity mouse	species reactivity human	species reactivity human

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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